TY - JOUR
T1 - Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion
AU - Silberstein, L.
AU - Davies, A.
AU - Kelsey, S.
AU - Foran, J.
AU - Murrell, C.
AU - D'Cruz, D.
AU - Vinnicombe, S.
AU - Norton, A.
AU - Cavenagh, J.
PY - 2001
Y1 - 2001
N2 - The clinical features of chronic graft-versus-host disease (cGVHD) following a non-myeloablative peripheral blood stem cell (PBSC) transplant may differ from those that occur after a conventional allograft. We describe a man with Hodkin's disease refractory to chemotherapy and radiotherapy who was transplanted from an HLA-identical brother, who developed cGVHD characterised, in particular, by polymyositis, polyserositis with a large pericardial effusion and constrictive pericarditis, 1 month after donor lymphocyte infusion for relapsed disease. Constrictive pericarditis has not been previously reported after a conventional allograft, and none of these features have been reported after a non-myeloablative transplant. The course of cGVHD necessitated potent immunosuppression leading to the presumed loss of graft-versus-lymphoma (GVL) effect.
AB - The clinical features of chronic graft-versus-host disease (cGVHD) following a non-myeloablative peripheral blood stem cell (PBSC) transplant may differ from those that occur after a conventional allograft. We describe a man with Hodkin's disease refractory to chemotherapy and radiotherapy who was transplanted from an HLA-identical brother, who developed cGVHD characterised, in particular, by polymyositis, polyserositis with a large pericardial effusion and constrictive pericarditis, 1 month after donor lymphocyte infusion for relapsed disease. Constrictive pericarditis has not been previously reported after a conventional allograft, and none of these features have been reported after a non-myeloablative transplant. The course of cGVHD necessitated potent immunosuppression leading to the presumed loss of graft-versus-lymphoma (GVL) effect.
KW - Constrictive pericarditis
KW - Graft-versus-host disease
KW - Myositis
KW - Pericardial effusion
KW - Polyserositis
UR - http://www.scopus.com/inward/record.url?scp=0035138538&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035138538&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1702775
DO - 10.1038/sj.bmt.1702775
M3 - Article
C2 - 11281399
AN - SCOPUS:0035138538
SN - 0268-3369
VL - 27
SP - 231
EP - 233
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 2
ER -