Myeloproliferative neoplasms: Thrombophilic clonal stem cell diseases

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are currently classified as BCR-ABL-negative classic myeloproliferative neoplasms (MPN). According to the revised 2008 World Health Organization (WHO) classification system, adult chronic myeloid neoplasms are now divided into four broad categories; myelodysplastic syndrome (MDS), MPN, "MDS/MPN overlap" and "myeloid or lymphoid neoplasms associated with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1" [1]. The WHO MPN category includes the four classic MPN: chronic myelogenous leukemia (CML; BCR-ABL-positive), PV, ET, and PMF. All three BCR-ABL-negative MPN are uncommon and incidence figures are estimated at 0.2-2.5/100,000 for ET [2-4], 0.4 to 1.5/100,000 for PMF [2, 3] and 0.8-2.6/100,000 for PV [5, 6]. The median age at diagnosis for all these three MPN is approximately 60∈years [7].

Original languageEnglish (US)
Title of host publicationCoagulation in Cancer
Number of pages23
StatePublished - 2009

Publication series

NameCancer Treatment and Research
ISSN (Print)0927-3042

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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