Myeloproliferative neoplasms: Morphology and clinical practice

Tiziano Barbui, Jürgen Thiele, Alessandro M. Vannucchi, Ayalew Tefferi

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


In myeloproliferative neoplasms (MPNs), controversy persists regarding the usefulness and reproducibility of bone marrow (BM) features. Disagreements concerning the WHO classification are mainly focused on the discrimination between essential thrombocythemia (ET) and prefibrotic/early primary myelofibrosis (prePMF) and prodromal polycythemia vera (PV). Criticism mostly refers to lack of standardization of distinctive BM features precluding correct morphological pattern recognition. The distinction between WHO-defined ET and prePMF is not trivial because outcome is significantly worse in prePMF. Morphology was generally considered to be non-specific for the diagnosis of PV. Recent studies have revealed under-diagnosis of morphologically and biologically consistent PV. Am. J. Hematol. 91:430-433, 2016.

Original languageEnglish (US)
Pages (from-to)430-433
Number of pages4
JournalAmerican journal of hematology
Issue number4
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Hematology


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