TY - CHAP
T1 - Myeloproliferative Neoplasms
T2 - Chronic Myelogenous Leukemia, Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis
AU - Tibes, Raoul
AU - Khera, Gurcharan Singh
AU - Mesa, Ruben A.
PY - 2012/9/20
Y1 - 2012/9/20
N2 - The myeloproliferative neoplasms are a group of clonal hematological (stem cell) disorders with terminal myeloid cell expansion in the peripheral blood. Originally described by William Dameshek in 1951 based on clinical and bone marrow similarities, in 2001 myeloproliferative neoplasms were classified by the World Health Organization Classification which was updated in 2008. Myeloproliferative neoplasms are classified into five major entities (acute myeloid and lymphoid leukemias are separate entities). Myeloproliferative neoplasms can be divided into "classic" forms, which are chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, and primary myelofibrosis, and "atypical" forms, consisting of chronic neutrophilic leukemia, chronic eosinophilic leukemia not otherwise specified, mastocytosis and myeloproliferative neoplasm unclassifiable. The four "classic" myeloproliferative neoplasms will be discussed in this chapter, given their rarity.
AB - The myeloproliferative neoplasms are a group of clonal hematological (stem cell) disorders with terminal myeloid cell expansion in the peripheral blood. Originally described by William Dameshek in 1951 based on clinical and bone marrow similarities, in 2001 myeloproliferative neoplasms were classified by the World Health Organization Classification which was updated in 2008. Myeloproliferative neoplasms are classified into five major entities (acute myeloid and lymphoid leukemias are separate entities). Myeloproliferative neoplasms can be divided into "classic" forms, which are chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, and primary myelofibrosis, and "atypical" forms, consisting of chronic neutrophilic leukemia, chronic eosinophilic leukemia not otherwise specified, mastocytosis and myeloproliferative neoplasm unclassifiable. The four "classic" myeloproliferative neoplasms will be discussed in this chapter, given their rarity.
KW - CEL
KW - CML
KW - CNL
KW - Essential thrombocythemia
KW - MPNs
KW - Polycythemia vera
KW - Primary myelofibrosis
KW - SM
UR - http://www.scopus.com/inward/record.url?scp=84886824051&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886824051&partnerID=8YFLogxK
U2 - 10.1002/9781118464557.ch47
DO - 10.1002/9781118464557.ch47
M3 - Chapter
AN - SCOPUS:84886824051
SN - 9781118083734
SP - 647
EP - 658
BT - Textbook of Uncommon Cancer
PB - John Wiley and Sons
ER -