MyD-88 L265P mutations are present in some cases of vitreoretinal lymphoma

Jose S Pulido; Diva R. Salomao; Lori A. Frederick; David S. Viswanatha

doi:10.1097/IAE.0000000000000589

MyD-88 L265P mutations are present in some cases of vitreoretinal lymphoma

Jose S Pulido, Diva R. Salomao, Lori A. Frederick, David S. Viswanatha

Ophthalmology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Purpose: To determine whether Myd88 L265P mutations occur in diffuse large B-cell vitreoretinal lymphomas. Methods: The formalin-fixed paraffin-embedded cells from three patients with classic clinical findings of vitreoretinal lymphoma that also had histologic confirmation were evaluated using a validated amplification-refractory mutation system polymerase chain reaction to determine the presence of the mutation. Results: The 74 ± 2 base pair product seen from the mutated Myd-88 protein was noted in 2 of the 3 cases. Conclusion: Myd-88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma. Further studies on the incidence of this mutation in retinal lymphomas are warranted.

Original language	English (US)
Pages (from-to)	624-627
Number of pages	4
Journal	Retina
Volume	35
Issue number	4
DOIs	https://doi.org/10.1097/IAE.0000000000000589
State	Published - Apr 1 2015

Keywords

CNS lymphoma
diffuse large B-cell lymphoma
Myd-88
Myd-88 L265P mutation
vitreoretinal lymphoma

ASJC Scopus subject areas

Ophthalmology

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10.1097/IAE.0000000000000589

Cite this

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title = "MyD-88 L265P mutations are present in some cases of vitreoretinal lymphoma",

abstract = "Purpose: To determine whether Myd88 L265P mutations occur in diffuse large B-cell vitreoretinal lymphomas. Methods: The formalin-fixed paraffin-embedded cells from three patients with classic clinical findings of vitreoretinal lymphoma that also had histologic confirmation were evaluated using a validated amplification-refractory mutation system polymerase chain reaction to determine the presence of the mutation. Results: The 74 ± 2 base pair product seen from the mutated Myd-88 protein was noted in 2 of the 3 cases. Conclusion: Myd-88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma. Further studies on the incidence of this mutation in retinal lymphomas are warranted.",

keywords = "CNS lymphoma, diffuse large B-cell lymphoma, Myd-88, Myd-88 L265P mutation, vitreoretinal lymphoma",

author = "Pulido, {Jose S} and Salomao, {Diva R.} and Frederick, {Lori A.} and Viswanatha, {David S.}",

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T1 - MyD-88 L265P mutations are present in some cases of vitreoretinal lymphoma

AU - Pulido, Jose S

AU - Salomao, Diva R.

AU - Frederick, Lori A.

AU - Viswanatha, David S.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Purpose: To determine whether Myd88 L265P mutations occur in diffuse large B-cell vitreoretinal lymphomas. Methods: The formalin-fixed paraffin-embedded cells from three patients with classic clinical findings of vitreoretinal lymphoma that also had histologic confirmation were evaluated using a validated amplification-refractory mutation system polymerase chain reaction to determine the presence of the mutation. Results: The 74 ± 2 base pair product seen from the mutated Myd-88 protein was noted in 2 of the 3 cases. Conclusion: Myd-88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma. Further studies on the incidence of this mutation in retinal lymphomas are warranted.

AB - Purpose: To determine whether Myd88 L265P mutations occur in diffuse large B-cell vitreoretinal lymphomas. Methods: The formalin-fixed paraffin-embedded cells from three patients with classic clinical findings of vitreoretinal lymphoma that also had histologic confirmation were evaluated using a validated amplification-refractory mutation system polymerase chain reaction to determine the presence of the mutation. Results: The 74 ± 2 base pair product seen from the mutated Myd-88 protein was noted in 2 of the 3 cases. Conclusion: Myd-88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma. Further studies on the incidence of this mutation in retinal lymphomas are warranted.

KW - CNS lymphoma

KW - diffuse large B-cell lymphoma

KW - Myd-88

KW - Myd-88 L265P mutation

KW - vitreoretinal lymphoma

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MyD-88 L265P mutations are present in some cases of vitreoretinal lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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