MyD-88 L265P mutations are present in some cases of vitreoretinal lymphoma

Jose S Pulido, Diva R. Salomao, Lori A. Frederick, David S. Viswanatha

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Purpose: To determine whether Myd88 L265P mutations occur in diffuse large B-cell vitreoretinal lymphomas. Methods: The formalin-fixed paraffin-embedded cells from three patients with classic clinical findings of vitreoretinal lymphoma that also had histologic confirmation were evaluated using a validated amplification-refractory mutation system polymerase chain reaction to determine the presence of the mutation. Results: The 74 ± 2 base pair product seen from the mutated Myd-88 protein was noted in 2 of the 3 cases. Conclusion: Myd-88 L265P constitutive activating mutations are present in at least some cases of the diffuse large B-cell lymphoma form of vitreoretinal lymphoma. Further studies on the incidence of this mutation in retinal lymphomas are warranted.

Original languageEnglish (US)
Pages (from-to)624-627
Number of pages4
Issue number4
StatePublished - Apr 1 2015


  • CNS lymphoma
  • diffuse large B-cell lymphoma
  • Myd-88
  • Myd-88 L265P mutation
  • vitreoretinal lymphoma

ASJC Scopus subject areas

  • Ophthalmology


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