@article{0fb94db7c5be4e669d3ce531bf7325eb,
title = "Multiple sclerosis masquerading as Alzheimer-type dementia: Clinical, radiological and pathological findings",
abstract = "Background and objectives: We report a comprehensive clinical, radiological, neuropsychometric and pathological evaluation of a woman with a clinical diagnosis of AD dementia (ADem), but whose autopsy demonstrated widespread demyelination, without Alzheimer disease (AD) pathology. Methods and results: Initial neuropsychometric evaluation suggested amnestic mild cognitive impairment (aMCI). Serial magnetic resonance images (MRI) images demonstrated the rate of increase in her ventricular volume was comparable to that of 46 subjects with aMCI who progressed to ADem, without accumulating white matter disease. Myelin immunohistochemistry at autopsy demonstrated extensive cortical subpial demyelination. Subpial lesions involved the upper cortical layers, and often extended through the entire width of the cortex. Conclusions: Multiple sclerosis (MS) can cause severe cortical dysfunction and mimic ADem. Cortical demyelination is not well detected by standard imaging modalities and may not be detected on autopsy without myelin immunohistochemistry.",
keywords = "Cortical demyelination, cognitive impairment, multiple sclerosis",
author = "Tobin, {W. O.} and Popescu, {B. F.} and V. Lowe and I. Pirko and Parisi, {J. E.} and K. Kantarci and Fields, {J. A.} and Bruns, {M. B.} and Boeve, {B. F.} and Lucchinetti, {C. F.}",
note = "Funding Information: Dr Tobin reports no disclosures. Dr Popescu served as a speaker for Teva Innovation Canada, received an honorarium for publishing in Continuum: Lifelong Learning in Neurology, and receives research support from the Canada Research Chairs program (principal investigator) and this work was supported by the Canada Research Chairs program. Dr Lowe serves as a consultant for Bayer Schering Pharma, Philips Molecular Imaging, Piramal Imaging and GE Healthcare and receives research support from GE Healthcare, Siemens Molecular Imaging, AVID Radio pharmaceuticals, the National Institutes of Health (National Institute on Aging (NIA), National Cancer Institute (NCI)), and the MN Partnership for Biotechnology and Medical Genomics. Dr Parisi receives publishing royalties for Principles&Practice of Neuropathology, Ed 2. Dr Kantarci serves on the data safety monitoring board for Pfizer Inc and Takeda Global Research&Development Center, Inc. Her research program is funded by the NIH and Minnesota Partnership for Biotechnology and Medical Genomics. Dr Fields reports no disclosures. Dr Bruns reports no disclosures. Dr Boeve is supported by grants P50 AG016574, RO1 AG011378, and the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer s Disease Research Program of the Mayo Foundation. Dr Lucchinetti is sponsored by grants: R01NS049577-01-A2 from the National Institutes of Health and Novartis. Publisher Copyright: {\textcopyright} SAGE Publications.",
year = "2016",
month = apr,
day = "1",
doi = "10.1177/1352458515604382",
language = "English (US)",
volume = "22",
pages = "698--704",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "5",
}