Multiple myeloma terminating in acute eosinophilic leukemia

Koichi Maeda, Ellis J. VanSlyck, Daniel L. VanDyke

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A 71-year-old woman with multiple myeloma was successfully managed for 8 years with melphalan (total dose 2056 mg). She developed a refractory anemia (myelodysplastic state), which terminated in acute eosinophilic leukemia. This form of acute leukemia, induced by chemotherapy, appears to be very rare. The cytogenetic changes, including 5q- and monosomy 7, were similar to those observed in other patients with acute nonlymphocytic leukemia as a secondary malignancy following treatments of other primary tumors.

Original languageEnglish (US)
Pages (from-to)81-89
Number of pages9
JournalCancer Genetics and Cytogenetics
Issue number1
StatePublished - Mar 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology


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