Multiple myeloma in older adults: an update

Madappa N. Kundranda, Joseph Mikhael

Research output: Contribution to journalArticlepeer-review


Multiple myeloma (MM) is an uncommon malignant plasma cell disorder that often presents in older adults. An accurate diagnosis is critical as a spectrum of plasma cell disorders have been defined, including monoclonal gammopathy of undetermined significance, smouldering/asymptomatic multiple myeloma, multiple myeloma, and plasma cell leukemia. Although multiple myeloma is incurable disease, survival over 7 years is possible, during which patients can enjoy a good quality of life. Many therapeutic options now exist for individuals with MM who are ineligible for autologous stem cell transplantation; these include adding thalidomide, bortezomib, and lenalidomide to the current standard ofmelphalan and prednisone.

Original languageEnglish (US)
Pages (from-to)382-388
Number of pages7
JournalGeriatrics and Aging
Issue number8
StatePublished - Sep 2009


  • MGUS
  • Multiple myeloma
  • Older adults
  • Plasma cell leukemia
  • Supportive care

ASJC Scopus subject areas

  • Aging
  • Gerontology
  • Geriatrics and Gerontology


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