Multiple myeloma in older adults: an update

Madappa N. Kundranda; Joseph Mikhael

Multiple myeloma in older adults: an update

Madappa N. Kundranda, Joseph Mikhael

Hematology/Oncology

Research output: Contribution to journal › Article › peer-review

Abstract

Multiple myeloma (MM) is an uncommon malignant plasma cell disorder that often presents in older adults. An accurate diagnosis is critical as a spectrum of plasma cell disorders have been defined, including monoclonal gammopathy of undetermined significance, smouldering/asymptomatic multiple myeloma, multiple myeloma, and plasma cell leukemia. Although multiple myeloma is incurable disease, survival over 7 years is possible, during which patients can enjoy a good quality of life. Many therapeutic options now exist for individuals with MM who are ineligible for autologous stem cell transplantation; these include adding thalidomide, bortezomib, and lenalidomide to the current standard ofmelphalan and prednisone.

Original language	English (US)
Pages (from-to)	382-388
Number of pages	7
Journal	Geriatrics and Aging
Volume	12
Issue number	8
State	Published - Sep 2009

Keywords

MGUS
Multiple myeloma
Older adults
Plasma cell leukemia
Supportive care

ASJC Scopus subject areas

Aging
Gerontology
Geriatrics and Gerontology

Cite this

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title = "Multiple myeloma in older adults: an update",

abstract = "Multiple myeloma (MM) is an uncommon malignant plasma cell disorder that often presents in older adults. An accurate diagnosis is critical as a spectrum of plasma cell disorders have been defined, including monoclonal gammopathy of undetermined significance, smouldering/asymptomatic multiple myeloma, multiple myeloma, and plasma cell leukemia. Although multiple myeloma is incurable disease, survival over 7 years is possible, during which patients can enjoy a good quality of life. Many therapeutic options now exist for individuals with MM who are ineligible for autologous stem cell transplantation; these include adding thalidomide, bortezomib, and lenalidomide to the current standard ofmelphalan and prednisone.",

keywords = "MGUS, Multiple myeloma, Older adults, Plasma cell leukemia, Supportive care",

author = "Kundranda, {Madappa N.} and Joseph Mikhael",

note = "Funding Information: Manuscript received August 30, 2006; revised December 1, 2006. The work of S. Kim was supported by the Nano-Systems Institute (NSI-NCRC) program sponsored by the Korea Science and Engineering Foundation (KOSEF). This paper was recommended by Associate Editor V. Kursun. S. Kim is with the Department of Electrical Engineering and Computer Science, Seoul National University, Seoul 151-744, Korea (e-mail: suhwan@snu.ac.kr). S. V. Kosonocky, D. R. Kneble, and K. Stawiasz are with the IBM T. J. Watson Research Center, Yorktown Heights, NY 10598 USA. M. C. Papaefthymiou is with the Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109 USA. Digital Object Identifier 10.1109/TCSII.2007.894428",

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T2 - an update

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AU - Mikhael, Joseph

N1 - Funding Information: Manuscript received August 30, 2006; revised December 1, 2006. The work of S. Kim was supported by the Nano-Systems Institute (NSI-NCRC) program sponsored by the Korea Science and Engineering Foundation (KOSEF). This paper was recommended by Associate Editor V. Kursun. S. Kim is with the Department of Electrical Engineering and Computer Science, Seoul National University, Seoul 151-744, Korea (e-mail: suhwan@snu.ac.kr). S. V. Kosonocky, D. R. Kneble, and K. Stawiasz are with the IBM T. J. Watson Research Center, Yorktown Heights, NY 10598 USA. M. C. Papaefthymiou is with the Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109 USA. Digital Object Identifier 10.1109/TCSII.2007.894428

PY - 2009/9

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N2 - Multiple myeloma (MM) is an uncommon malignant plasma cell disorder that often presents in older adults. An accurate diagnosis is critical as a spectrum of plasma cell disorders have been defined, including monoclonal gammopathy of undetermined significance, smouldering/asymptomatic multiple myeloma, multiple myeloma, and plasma cell leukemia. Although multiple myeloma is incurable disease, survival over 7 years is possible, during which patients can enjoy a good quality of life. Many therapeutic options now exist for individuals with MM who are ineligible for autologous stem cell transplantation; these include adding thalidomide, bortezomib, and lenalidomide to the current standard ofmelphalan and prednisone.

AB - Multiple myeloma (MM) is an uncommon malignant plasma cell disorder that often presents in older adults. An accurate diagnosis is critical as a spectrum of plasma cell disorders have been defined, including monoclonal gammopathy of undetermined significance, smouldering/asymptomatic multiple myeloma, multiple myeloma, and plasma cell leukemia. Although multiple myeloma is incurable disease, survival over 7 years is possible, during which patients can enjoy a good quality of life. Many therapeutic options now exist for individuals with MM who are ineligible for autologous stem cell transplantation; these include adding thalidomide, bortezomib, and lenalidomide to the current standard ofmelphalan and prednisone.

KW - MGUS

KW - Multiple myeloma

KW - Older adults

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KW - Supportive care

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ER -

Multiple myeloma in older adults: an update

Abstract

Keywords

ASJC Scopus subject areas

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