TY - JOUR
T1 - Multiorgan locked-state model of chronic diseases and systems pharmacology opportunities
AU - Ung, Choong Yong
AU - Correia, Cristina
AU - Li, Hu
AU - Adams, Christopher M.
AU - Westendorf, Jennifer J
AU - Zhu, Shizhen
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2024/1
Y1 - 2024/1
N2 - With increasing human life expectancy, the global medical burden of chronic diseases is growing. Hence, chronic diseases are a pressing health concern and will continue to be in decades to come. Chronic diseases often involve multiple malfunctioning organs in the body. An imminent question is how interorgan crosstalk contributes to the etiology of chronic diseases. We conceived the locked-state model (LoSM), which illustrates how interorgan communication can give rise to body-wide memory-like properties that ‘lock’ healthy or pathological conditions. Next, we propose cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. Finally, we discuss the clinical implications of the LoSM and assess the power of systems-based therapies to dismantle pathological multiorgan locked states while improving treatments for chronic diseases.
AB - With increasing human life expectancy, the global medical burden of chronic diseases is growing. Hence, chronic diseases are a pressing health concern and will continue to be in decades to come. Chronic diseases often involve multiple malfunctioning organs in the body. An imminent question is how interorgan crosstalk contributes to the etiology of chronic diseases. We conceived the locked-state model (LoSM), which illustrates how interorgan communication can give rise to body-wide memory-like properties that ‘lock’ healthy or pathological conditions. Next, we propose cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. Finally, we discuss the clinical implications of the LoSM and assess the power of systems-based therapies to dismantle pathological multiorgan locked states while improving treatments for chronic diseases.
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U2 - 10.1016/j.drudis.2023.103825
DO - 10.1016/j.drudis.2023.103825
M3 - Review article
C2 - 37967790
AN - SCOPUS:85178031750
SN - 1359-6446
VL - 29
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 1
M1 - 103825
ER -