@inproceedings{bf50981fa04f4c78923f0a0d3e1aa999,
title = "Multimodal imaging of vascular grafts using time-resolved fluorescence and ultrasound",
abstract = "The translation of engineered tissues into clinic requires robust monitoring of tissue development, both in vitro and in vivo. Traditional methods for the same are destructive, inefficient in time and cost and do not allow time-lapse measurements from the same sample or animal. This study reports on the ability of time-resolved fluorescence and ultrasound measurements for non-destructive characterization of explanted tissue engineered vascular grafts. Results show that TRFS and FLIm are able to assess alterations in luminal composition namely elastin, collagen and cellular (hyperplasia) content via changes in fluorescence lifetime values between normal and grafted tissue. These observations are complemented by structural changes observed in UBM pertaining to graft integration and intimal thickness over the grafted region. These results encourage the future application of a catheter-based technique that combines these imaging modalities for non-destructive characterization of vascular grafts in vivo.",
keywords = "Time-resolved fluorescence, Tissue characterization, Tissue engineering, Ultrasound, Vascular grafts",
author = "Hussain Fatakdawala and Griffiths, {Leigh G.} and Sterling Humphrey and Laura Marcu",
year = "2015",
doi = "10.1117/12.2078278",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Kang, {Hyun Wook} and Ilgner, {Justus F.} and Skala, {Melissa C.} and Laura Marcu and Haishan Zeng and Dewhirst, {Mark W.} and Gregory, {Kenton W.} and Andreas Mandelis and Bernard Choi and Wong, {Brian Jet-Fei} and Claus-Peter Richter and Tearney, {Guillermo J.} and Alfred Nuttal and Nikiforos Kollias",
booktitle = "Photonic Therapeutics and Diagnostics XI",
note = "Photonic Therapeutics and Diagnostics XI ; Conference date: 07-02-2015 Through 08-02-2015",
}