Multifocal malignant melanoma arising in vesicovaginal melanosis

S. W. Kerley, M. L. Blute, Gary Keeney

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


An 80-year-old white woman developed vulvar melanosis and malignant melanoma of the labia majora and clitoris and underwent a simple vulvectomy. She subsequently developed melanosis of the urinary bladder and presented 3 years later with multifocal malignant melanoma involving the vagina, urethra, and urinary bladder in a background of extensive melanosis with variable degrees of atypia. She underwent radical surgery but died 18 months later with liver metastases and liver failure. Malignant melanoma is uncommon in the vulva and vagina and is rare in the urinary bladder. This case illustrates the previously described association between melanosis and malignant melanoma. The unusual features are the widespread distribution of the melanosis (vagina and bladder) and the subsequent development of multifocal malignant melanoma.

Original languageEnglish (US)
Pages (from-to)950-952
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Issue number9
StatePublished - 1991

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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