We studied two cases of a recently recognized systemic lymphoproliferative disease with morphologic features of Castleman's disease: multicentric giant lymph node hyperplasia. Both patients developed Kaposi's sarcoma and had laboratory evidence of immune abnormalities, including reversed T4 to T8 ratios. One patient's disease had a subacute course with fevers of unknown origin, mucocutaneous candidiasis, and progressive thrombocytopenia, while the other patient's disease had a fulminant course with anemia, thrombocytopenia, and splenic lymphoma. Both patients were elderly, and both died of complications of multicentric giant lymph node hyperplasia.
|Number of pages
|Archives of Pathology and Laboratory Medicine
|Published - 1985
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology