Multicentric giant lymph node hyperplasia, Kaposi's sarcoma, and lymphoma

Dennis W Dickson, J. M. Ben-Ezra, J. Reed, H. Flax, R. Janis

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


We studied two cases of a recently recognized systemic lymphoproliferative disease with morphologic features of Castleman's disease: multicentric giant lymph node hyperplasia. Both patients developed Kaposi's sarcoma and had laboratory evidence of immune abnormalities, including reversed T4 to T8 ratios. One patient's disease had a subacute course with fevers of unknown origin, mucocutaneous candidiasis, and progressive thrombocytopenia, while the other patient's disease had a fulminant course with anemia, thrombocytopenia, and splenic lymphoma. Both patients were elderly, and both died of complications of multicentric giant lymph node hyperplasia.

Original languageEnglish (US)
Pages (from-to)1013-1018
Number of pages6
JournalArchives of Pathology and Laboratory Medicine
Issue number11
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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