Multicenter trial of the proficiency of smart quantitative sensation tests

Peter J. Dyck; Barbara Argyros; James W. Russell; Linde E. Gahnstrom; Susan Nalepa; James W. Albers; Karen A. Lodermeier; Andrew J. Zafft; P. James B. Dyck; Christopher J. Klein; William J. Litchy; Jenny L. Davies; Rickey E. Carter; L. Joseph Melton; Phillip A. Low; Carol J. Overland; Henning Andersen; John D. England; Gareth Llewelyn; Michelle L. Mauermann; Dinesh Selvarajah; Wolfgang Singer; Gordon Smith; Solomon Tesfaye; Adrian Vella

doi:10.1002/mus.23982

Multicenter trial of the proficiency of smart quantitative sensation tests

Peter J. Dyck, Barbara Argyros, James W. Russell, Linde E. Gahnstrom, Susan Nalepa, James W. Albers, Karen A. Lodermeier, Andrew J. Zafft, P. James B. Dyck, Christopher J. Klein, William J. Litchy, Jenny L. Davies, Rickey E. Carter, L. Joseph Melton, Phillip A. Low, Carol J. Overland, Henning Andersen, John D. England, Gareth Llewelyn, Michelle L. MauermannDinesh Selvarajah, Wolfgang Singer, Gordon Smith, Solomon Tesfaye, Adrian Vella

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Introduction: We assessed proficiency (accuracy and intra- and intertest reproducibility) of smart quantitative sensation tests (smart QSTs) in subjects without and with diabetic sensorimotor polyneuropathy (DSPN). Methods: Technologists from 3 medical centers using different but identical QSTs independently assessed 6 modalities of sensation of the foot (or leg) twice in patients without (n=6) and with (n=6) DSPN using smart computer assisted QSTs. Results: Low rates of test abnormalities were observed in health and high rates in DSPN. Very high intraclass correlations were obtained between continuous measures of QSTs and neuropathy signs, symptoms, or nerve conductions (NCs). No significant intra- or intertest differences were observed. Conclusions: These results provide proof of concept that smart QSTs provide accurate assessment of sensation loss without intra-or intertest differences useful for multicenter trials. Smart technology makes possible efficient testing of body surface area sensation loss in symmetric length-dependent sensorimotor polyneuropathies.

Original language	English (US)
Pages (from-to)	645-653
Number of pages	9
Journal	Muscle and Nerve
Volume	49
Issue number	5
DOIs	https://doi.org/10.1002/mus.23982
State	Published - May 2014

Keywords

Accuracy and reliability of nerve tests
Diabetic sensorimotor polyneuropathy
Intra- and intertest reproducibility
Neurophysiology tests
Smart quantitative sensation tests

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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Dyck, P. J., Argyros, B., Russell, J. W., Gahnstrom, L. E., Nalepa, S., Albers, J. W., Lodermeier, K. A., Zafft, A. J., Dyck, P. J. B., Klein, C. J., Litchy, W. J., Davies, J. L., Carter, R. E., Melton, L. J., Low, P. A., Overland, C. J., Andersen, H., England, J. D., Llewelyn, G., ... Vella, A. (2014). Multicenter trial of the proficiency of smart quantitative sensation tests. Muscle and Nerve, 49(5), 645-653. https://doi.org/10.1002/mus.23982

Dyck, PJ, Argyros, B, Russell, JW, Gahnstrom, LE, Nalepa, S, Albers, JW, Lodermeier, KA, Zafft, AJ, Dyck, PJB , Klein, CJ , Litchy, WJ, Davies, JL, Carter, RE, Melton, LJ, Low, PA, Overland, CJ, Andersen, H, England, JD, Llewelyn, G, Mauermann, ML, Selvarajah, D, Singer, W, Smith, G, Tesfaye, S & Vella, A 2014, 'Multicenter trial of the proficiency of smart quantitative sensation tests', Muscle and Nerve, vol. 49, no. 5, pp. 645-653. https://doi.org/10.1002/mus.23982

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abstract = "Introduction: We assessed proficiency (accuracy and intra- and intertest reproducibility) of smart quantitative sensation tests (smart QSTs) in subjects without and with diabetic sensorimotor polyneuropathy (DSPN). Methods: Technologists from 3 medical centers using different but identical QSTs independently assessed 6 modalities of sensation of the foot (or leg) twice in patients without (n=6) and with (n=6) DSPN using smart computer assisted QSTs. Results: Low rates of test abnormalities were observed in health and high rates in DSPN. Very high intraclass correlations were obtained between continuous measures of QSTs and neuropathy signs, symptoms, or nerve conductions (NCs). No significant intra- or intertest differences were observed. Conclusions: These results provide proof of concept that smart QSTs provide accurate assessment of sensation loss without intra-or intertest differences useful for multicenter trials. Smart technology makes possible efficient testing of body surface area sensation loss in symmetric length-dependent sensorimotor polyneuropathies.",

keywords = "Accuracy and reliability of nerve tests, Diabetic sensorimotor polyneuropathy, Intra- and intertest reproducibility, Neurophysiology tests, Smart quantitative sensation tests",

author = "Dyck, {Peter J.} and Barbara Argyros and Russell, {James W.} and Gahnstrom, {Linde E.} and Susan Nalepa and Albers, {James W.} and Lodermeier, {Karen A.} and Zafft, {Andrew J.} and Dyck, {P. James B.} and Klein, {Christopher J.} and Litchy, {William J.} and Davies, {Jenny L.} and Carter, {Rickey E.} and Melton, {L. Joseph} and Low, {Phillip A.} and Overland, {Carol J.} and Henning Andersen and England, {John D.} and Gareth Llewelyn and Mauermann, {Michelle L.} and Dinesh Selvarajah and Wolfgang Singer and Gordon Smith and Solomon Tesfaye and Adrian Vella",

year = "2014",

month = may,

doi = "10.1002/mus.23982",

language = "English (US)",

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AU - Dyck, Peter J.

AU - Argyros, Barbara

AU - Russell, James W.

AU - Gahnstrom, Linde E.

AU - Nalepa, Susan

AU - Albers, James W.

AU - Lodermeier, Karen A.

AU - Zafft, Andrew J.

AU - Dyck, P. James B.

AU - Klein, Christopher J.

AU - Litchy, William J.

AU - Davies, Jenny L.

AU - Carter, Rickey E.

AU - Melton, L. Joseph

AU - Low, Phillip A.

AU - Overland, Carol J.

AU - Andersen, Henning

AU - England, John D.

AU - Llewelyn, Gareth

AU - Mauermann, Michelle L.

AU - Selvarajah, Dinesh

AU - Singer, Wolfgang

AU - Smith, Gordon

AU - Tesfaye, Solomon

AU - Vella, Adrian

PY - 2014/5

Y1 - 2014/5

N2 - Introduction: We assessed proficiency (accuracy and intra- and intertest reproducibility) of smart quantitative sensation tests (smart QSTs) in subjects without and with diabetic sensorimotor polyneuropathy (DSPN). Methods: Technologists from 3 medical centers using different but identical QSTs independently assessed 6 modalities of sensation of the foot (or leg) twice in patients without (n=6) and with (n=6) DSPN using smart computer assisted QSTs. Results: Low rates of test abnormalities were observed in health and high rates in DSPN. Very high intraclass correlations were obtained between continuous measures of QSTs and neuropathy signs, symptoms, or nerve conductions (NCs). No significant intra- or intertest differences were observed. Conclusions: These results provide proof of concept that smart QSTs provide accurate assessment of sensation loss without intra-or intertest differences useful for multicenter trials. Smart technology makes possible efficient testing of body surface area sensation loss in symmetric length-dependent sensorimotor polyneuropathies.

AB - Introduction: We assessed proficiency (accuracy and intra- and intertest reproducibility) of smart quantitative sensation tests (smart QSTs) in subjects without and with diabetic sensorimotor polyneuropathy (DSPN). Methods: Technologists from 3 medical centers using different but identical QSTs independently assessed 6 modalities of sensation of the foot (or leg) twice in patients without (n=6) and with (n=6) DSPN using smart computer assisted QSTs. Results: Low rates of test abnormalities were observed in health and high rates in DSPN. Very high intraclass correlations were obtained between continuous measures of QSTs and neuropathy signs, symptoms, or nerve conductions (NCs). No significant intra- or intertest differences were observed. Conclusions: These results provide proof of concept that smart QSTs provide accurate assessment of sensation loss without intra-or intertest differences useful for multicenter trials. Smart technology makes possible efficient testing of body surface area sensation loss in symmetric length-dependent sensorimotor polyneuropathies.

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Multicenter trial of the proficiency of smart quantitative sensation tests

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Keywords

ASJC Scopus subject areas

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