Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias

Lisa Mosconi, Wai H. Tsui, Karl Herholz, Alberto Pupi, Alexander Drzezga, Giovanni Lucignani, Eric M. Reiman, Vjera Holthoff, Elke Kalbe, Sandro Sorbi, Janine Diehl-Schmid, Robert Perneczky, Francesca Clerici, Richard Caselli, Bettina Beuthien-Baumann, Alexander Kurz, Satoshi Minoshima, Mony J. De Leon

Research output: Contribution to journalArticlepeer-review

474 Scopus citations


This multicenter study examined 18F-FDG PET measures in the differential diagnosis of Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB) from normal aging and from each other and the relation of disease-specific patterns to mild cognitive impairment (MCI). Methods: We examined the 18F-FDG PET scans of 548 subjects, including 110 healthy elderly individuals ("normals" or NLs), 114 MCI, 199 AD, 98 FTD, and 27 DLB patients, collected at 7 participating centers. Individual PET scans were Z scored using automated voxel-based comparison with generation of disease-specific patterns of cortical and hippocampal 18F-FDG uptake that were then applied to characterize MCI. Results: Standardized disease-specific PET patterns were developed that correctly classified 95% AD, 92% DLB, 94% FTD, and 94% NL. MCI patients showed primarily posterior cingulate cortex and hippocampal hypometabolism (81%), whereas neocortical abnormalities varied according to neuropsychological profiles. An AD PET pattern was observed in 79% MCI with deficits in multiple cognitive domains and 31% amnesic MCI. 18F-FDG PET heterogeneity in MCI with non-memory deficits ranged from absent hypometabolism to FTD and DLB PET patterns. Conclusion: Standardized automated analysis of 18F-FDG PET scans may provide an objective and sensitive support to the clinical diagnosis in early dementia.

Original languageEnglish (US)
Pages (from-to)390-398
Number of pages9
JournalJournal of Nuclear Medicine
Issue number3
StatePublished - Mar 1 2008


  • Alzheimer's disease
  • Frontotemporal dementia
  • Hippocampus
  • Lewy body dementia
  • Mild cognitive impairment
  • Normal aging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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