Multicenter observational study of abobotulinumtoxinA neurotoxin in cervical dystonia: The ANCHOR-CD registry

Richard M. Trosch, Alberto J. Espay, Daniel Truong, Ramon Gil, Carlos Singer, Peter A. LeWitt, Mark F. Lew, Michele Tagliati, Charles H. Adler, Jack J. Chen, Dominic Marchese, Cynthia L. Comella

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Background The ANCHOR-CD prospective observational registry study evaluated the effectiveness of abobotulinumtoxinA in adult idiopathic cervical dystonia (CD) in clinical practice. Methods Adults with CD were eligible. Treating physicians determined abobotulinumtoxinA dose and treatment interval. The primary endpoint was patient response rate (Toronto Western Spasmodic Torticollis Rating Scale [TWSTRS] score reduction ≥ 25% and Patient Global Impression of Change [PGIC] score of + 2 or + 3 at Week 4 of Cycle 1). Results 350 patients enrolled (75% women; mean age 59 ± 13.6 years; 27.4% botulinum neurotoxin-naive) and 347 received at least 1 treatment. The median abobotulinumtoxinA dose for Cycle 1 was 500 Units. At Week 4, the responder rate was 30.6% (n = 304) and the TWSTRS total score decreased 27.4% from baseline. PGIC of at least “Much improved” was documented in 43.6% of patients and maintained in Cycles 2 through 4 (43.3%, 48.9%, and 52.8%, respectively). A total of 39 adverse events (31 study drug-related) were reported in 17 patients (5%); the most common were dysphagia (n = 6), muscle weakness (n = 4), and neck pain (n = 3). Conclusion This study confirmed the beneficial effect of abobotulinumtoxinA on CD in routine clinical practice as measured by improvements in TWSTRS and PGIC. No new safety concerns were identified.

Original languageEnglish (US)
Pages (from-to)84-90
Number of pages7
JournalJournal of the neurological sciences
StatePublished - May 15 2017


  • AbobotulinumtoxinA
  • Botulinum toxin
  • Cervical dystonia
  • Cervical pain
  • Disability
  • Torticollis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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