Abstract
The mechanistic target of rapamycin (mTOR) signaling pathway integrates environmental signals and cellular metabolism to regulate T cell development, activation and differentiation. Recent studies reveal the importance of exquisite control of mTOR activity for proper T cell function, and detailed molecular mechanisms that regulate mTOR signaling in different T cell subsets. Here, we review the latest advances in our understanding of the mTOR pathway and its regulation in the differentiation and function of regulatory T cells and effector T cells.
Original language | English (US) |
---|---|
Pages (from-to) | 103-111 |
Number of pages | 9 |
Journal | Current Opinion in Immunology |
Volume | 46 |
DOIs | |
State | Published - Jun 2017 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology