MTOR inhibitors: Changing landscape of endocrine-resistant breast cancer

Saranya Chumsri, Gauri Sabnis, Katherine Tkaczuk, Angela Brodie

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Most breast cancer (BC) patients have tumors that express hormone receptors (HRs). Although endocrine therapy, such as aromatase inhibitors, is very effective, most patients with metastatic HR-positive (HR+) BC become resistant to endocrine therapy at some point in their treatment and subsequently require chemotherapy. The PI3K/mTOR pathway is often upregulated in endocrine-resistant BC patients and, therefore, has been one of the targets for development of new agents. Recently, a Phase III trial (BOLERO-2) in aromatase inhibitor-resistant BC patients showed a significant improvement in time to progression with the combination of everolimus and exemestane compared with exemestane alone, confirming the importance of the PI3K/mTOR pathway in endocrine-resistant BC. Side effects from mTOR inhibitors are manageable, but early detection and proactive management are required to ensure patients' safety, compliance and continuity of treatment. Thus, mTOR inhibitors offer a new hope and promise for patients with HR+ BC.

Original languageEnglish (US)
Pages (from-to)443-456
Number of pages14
JournalFuture Oncology
Issue number3
StatePublished - Feb 1 2014


  • Aromatase inhibitor
  • Breast cancer
  • Endocrine resistance
  • Hormone receptor
  • mTOR inhibitor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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