mTOR and metabolic regulation of conventional and regulatory t cells

Chaohong Liu; Nicole M. Chapman; Peer W.F. Karmaus; Hu Zeng; Hongbo Chi

doi:10.1189/jlb.2RI0814-408R

mTOR and metabolic regulation of conventional and regulatory t cells

Chaohong Liu, Nicole M. Chapman, Peer W.F. Karmaus, Hu Zeng, Hongbo Chi

Rheumatology

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

mTOR signaling links bioenergetic and biosynthetic metabolism to immune responses. mTOR is activated by diverse upstream stimuli, including immune signals, growth factors, and nutrients. Recent studies highlight crucial roles of mTOR signaling in immune functions mediated by conventional T cells and T_regs.

Original language	English (US)
Pages (from-to)	837-847
Number of pages	11
Journal	Journal of Leukocyte Biology
Volume	97
Issue number	5
DOIs	https://doi.org/10.1189/jlb.2RI0814-408R
State	Published - May 1 2015

Keywords

Glycolysis
Lipid
Metabolism
T
T cell differentiation

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Cell Biology

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10.1189/jlb.2RI0814-408R

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title = "mTOR and metabolic regulation of conventional and regulatory t cells",

abstract = "mTOR signaling links bioenergetic and biosynthetic metabolism to immune responses. mTOR is activated by diverse upstream stimuli, including immune signals, growth factors, and nutrients. Recent studies highlight crucial roles of mTOR signaling in immune functions mediated by conventional T cells and Tregs.",

keywords = "Glycolysis, Lipid, Metabolism, T, T cell differentiation",

author = "Chaohong Liu and Chapman, {Nicole M.} and Karmaus, {Peer W.F.} and Hu Zeng and Hongbo Chi",

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AU - Liu, Chaohong

AU - Chapman, Nicole M.

AU - Karmaus, Peer W.F.

AU - Zeng, Hu

AU - Chi, Hongbo

N1 - Publisher Copyright: © Society for Leukocyte Biology.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - mTOR signaling links bioenergetic and biosynthetic metabolism to immune responses. mTOR is activated by diverse upstream stimuli, including immune signals, growth factors, and nutrients. Recent studies highlight crucial roles of mTOR signaling in immune functions mediated by conventional T cells and Tregs.

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KW - Metabolism

KW - T

KW - T cell differentiation

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mTOR and metabolic regulation of conventional and regulatory t cells

Abstract

Keywords

ASJC Scopus subject areas

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