TY - JOUR
T1 - MTOR and lymphocyte metabolism
AU - Zeng, Hu
AU - Chi, Hongbo
N1 - Funding Information:
We acknowledge the large number of researchers who have contributed to this field whose work was not cited owing to space limitations. The authors’ research is supported by US National Institutes of Health ( R01 NS064599 and R21 AI094089 ), National Multiple Sclerosis Society , Lupus Research Institute , and the American Lebanese Syrian Associated Charities (HC).
PY - 2013/6
Y1 - 2013/6
N2 - Upon antigen engagement and proper co-stimulation, naïve lymphocytes exit quiescence and undergo clonal expansion and differentiate into functional effector cells, after which they either die through apoptosis or survive as memory cells. Lymphocytes at different activation stages exhibit distinct metabolic signatures. Emerging evidence highlights a central role for the mechanistic target of rapamycin (mTOR) in bridging immune signals and metabolic cues to direct lymphocyte proliferation, differentiation and survival. Here we review recent advances in understanding the functional significance and signal transduction of mTOR in T cell biology, and the interplay between mTOR signaling and metabolic programs.
AB - Upon antigen engagement and proper co-stimulation, naïve lymphocytes exit quiescence and undergo clonal expansion and differentiate into functional effector cells, after which they either die through apoptosis or survive as memory cells. Lymphocytes at different activation stages exhibit distinct metabolic signatures. Emerging evidence highlights a central role for the mechanistic target of rapamycin (mTOR) in bridging immune signals and metabolic cues to direct lymphocyte proliferation, differentiation and survival. Here we review recent advances in understanding the functional significance and signal transduction of mTOR in T cell biology, and the interplay between mTOR signaling and metabolic programs.
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U2 - 10.1016/j.coi.2013.05.002
DO - 10.1016/j.coi.2013.05.002
M3 - Review article
C2 - 23722114
AN - SCOPUS:84879195658
SN - 0952-7915
VL - 25
SP - 347
EP - 355
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 3
ER -