MR spectroscopy in schizophrenia

John D. Port, Nivedita Agarwal

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


The purpose of this study is to review the MR spectroscopic literature regarding schizophrenia. However, as there are over 250 primary MRS articles and dozens of MRS review articles on the subject already, this study will take a different approach. First, the clinical features of schizophrenia will be described. The background neuroanatomy and biochemistry relevant to schizophrenia will be reviewed, as many readers of this journal are unlikely to be familiar with these fields. A current model of the abnormal neural circuitry in schizophrenia will be presented, and predictions extrapolated about relevant metabolite changes over time. Finally, the existing MRS literature will be reviewed in the context of our existing anatomical and chemical knowledge, and future MRS research directions will be elaborated.

Original languageEnglish (US)
Pages (from-to)1251-1261
Number of pages11
JournalJournal of Magnetic Resonance Imaging
Issue number6
StatePublished - Dec 2011


  • GABA
  • MR spectroscopy
  • glutamate
  • metabolites
  • neural circuitry
  • schizophrenia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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