TY - JOUR
T1 - Movin' on up
T2 - the role of PtdIns(4,5)P2 in cell migration
AU - Ling, Kun
AU - Schill, Nicholas J.
AU - Wagoner, Matthew P.
AU - Sun, Yue
AU - Anderson, Richard A.
N1 - Funding Information:
We apologize to those whose work could not be cited because of space limitations. Research in the authors' laboratory is supported by NIH grants GM057549, GM51968 and CA104708. K.L. is supported by an American Heart Association (AHA) fellowship #0425731Z and AHA National Scientist Development Grant #0535552N. N.J.S. is supported by NIH T32 HL007899. M.P.W. is supported by NIH T32 GM08688. Y.S. is supported by AHA Postdoctoral fellowship #05201212.
PY - 2006/6
Y1 - 2006/6
N2 - Cell migration requires the coordination of many biochemical events, including cell-matrix contact turnover and cytoskeletal restructuring. Recent advances further implicate phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P2] in the control of these events. Many proteins that are crucial to the assembly of the migration machinery are regulated by PtdIns(4,5)P2. Coordinated synthesis of PtdIns(4,5)P2 at these sites is dependent on the precise targeting of the type I phosphatidylinositol phosphate kinases (PIPKs). Two PIPKI isoforms target to, and generate, PtdIns(4,5)P2 at membrane ruffles and focal adhesions during cell migration. Here, we discuss our current understanding of PtdIns(4,5)P2 in the regulation of cell responses to migratory stimuli and how the migrating cell controls PtdIns(4,5)P2 availability.
AB - Cell migration requires the coordination of many biochemical events, including cell-matrix contact turnover and cytoskeletal restructuring. Recent advances further implicate phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P2] in the control of these events. Many proteins that are crucial to the assembly of the migration machinery are regulated by PtdIns(4,5)P2. Coordinated synthesis of PtdIns(4,5)P2 at these sites is dependent on the precise targeting of the type I phosphatidylinositol phosphate kinases (PIPKs). Two PIPKI isoforms target to, and generate, PtdIns(4,5)P2 at membrane ruffles and focal adhesions during cell migration. Here, we discuss our current understanding of PtdIns(4,5)P2 in the regulation of cell responses to migratory stimuli and how the migrating cell controls PtdIns(4,5)P2 availability.
UR - http://www.scopus.com/inward/record.url?scp=33745001190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745001190&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2006.03.007
DO - 10.1016/j.tcb.2006.03.007
M3 - Review article
C2 - 16616849
AN - SCOPUS:33745001190
SN - 0962-8924
VL - 16
SP - 276
EP - 284
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 6
ER -