Mouse 5-HT(2B) receptor-mediated serotonin trophic functions

D. S. Choi, O. Kellermann, S. Richard, J. F. Colas, F. Bolaños-Jimenez, C. Tournois, J. M. Launay, L. Maroteaux

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


5-HT(2B) receptors, in addition to phospholipase C stimulation, are able to trigger activation of the proto-oncogene product p21(ras). During mouse embryogenesis, a peak of 5-HT(2B) receptor expression is detected at the neurulation stage; we localized the 5-HT(2B) expression in neural crest cells, heart myocardium, and somites. The requirement for functional 5-HT(2B) receptors shortly after gastrulation, is supported by culture of embryos exposed to 5-HT(2B)-high affinity antagonist such as ritanserin, which induces morphological defects in the cephalic region, heart and neural tube. Functional 5-HT(2B) receptors are also expressed during the serotonergic differentiation of the mouse F9 teratocarcinoma-derived clonal cell line 1C11. Upon 2 days of induction by cAMP, 5-HT(2B) receptors become functional, and on day 4, the appearance of 5-HT(2A) receptors coincides with the onset of active serotonin transporter by these cells. Active serotonin uptake is modulated by serotonin suggesting autoreceptor functions for 5-HT(2B) receptors.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalAnnals of the New York Academy of Sciences
StatePublished - 1998

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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