5-HT(2B) receptors, in addition to phospholipase C stimulation, are able to trigger activation of the proto-oncogene product p21(ras). During mouse embryogenesis, a peak of 5-HT(2B) receptor expression is detected at the neurulation stage; we localized the 5-HT(2B) expression in neural crest cells, heart myocardium, and somites. The requirement for functional 5-HT(2B) receptors shortly after gastrulation, is supported by culture of embryos exposed to 5-HT(2B)-high affinity antagonist such as ritanserin, which induces morphological defects in the cephalic region, heart and neural tube. Functional 5-HT(2B) receptors are also expressed during the serotonergic differentiation of the mouse F9 teratocarcinoma-derived clonal cell line 1C11. Upon 2 days of induction by cAMP, 5-HT(2B) receptors become functional, and on day 4, the appearance of 5-HT(2A) receptors coincides with the onset of active serotonin transporter by these cells. Active serotonin uptake is modulated by serotonin suggesting autoreceptor functions for 5-HT(2B) receptors.
|Original language||English (US)|
|Number of pages||7|
|Journal||Annals of the New York Academy of Sciences|
|State||Published - 1998|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science