Abstract
Mice deficient in pregnancy-associated plasma protein-A (PAPP-A), an IGF binding protein protease, have been shown to be resistant to experimentally induced atherosclerosis and diabetic nephropathy, and, in the laboratory environment, live 30-40% longer than wild-type littermates in association with delayed incidence and occurrence of age-related neoplasms and degenerative diseases. Objective: PAPP-A is highly expressed in the cerebellum and hippocampus of the mouse brain. Therefore, the studies presented here were aimed at determining motor behavior, learning and retention in PAPP-A knock-out (KO) mice compared to wild-type (WT) littermates with age. Design: Balance and coordination were assessed using an accelerating rotarod; learning and memory were assessed in a Stone T-maze. Results: Time on the rotarod decreased with age but there was no significant difference between PAPP-A KO and WT mice at any of the testing ages. Latency to reach the goal box and number of errors committed in the Stone T-maze did not change with age and there were no significant differences between PAPP-A KO and WT mice. Conclusion: Lack of PAPP-A in mice did not impact central regulation of coordination, learning or memory.
Original language | English (US) |
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Pages (from-to) | 251-255 |
Number of pages | 5 |
Journal | Growth Hormone and IGF Research |
Volume | 24 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1 2014 |
Keywords
- Pregnancy-associated plasma protein-A
- Rotarod
- Stone T-maze
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology