TY - JOUR
T1 - Morphometry of myelinated fibers of fasciculus gracilis of man
AU - Ohnishi, Akio
AU - O'Brien, Peter C.
AU - Okazaki, Haruo
AU - Dyck, Peter James
N1 - Funding Information:
INTRODUCTION Morphometry of sampled peripheral nerve from the appropriate level of spinal ganglion and posterior column may, in favorable cases, reveal three-dimensional pathologic alteration of primary afferent neurons and provide an insight into the mechanism of their degeneration (Ohnishi and Dyck 1974; Ohnishi, Siekert, Okazaki and Dyck 1976). Morphometric methods and normative data for the sural nerve (Dyck, Gutrecht, Bastron, Karnes and Dale 1968; Dyck, Ellefson, Lais, Smith, This investigation was supported in part by Research Grants 2200, MDA-8 and Upton Fund. Send reprint requests to Dr. Peter James Dyck.
PY - 1976/2
Y1 - 1976/2
N2 - The number of myelinated fibers per square millimeter of fasciculus gracilis, and of large and small myelinated fibers per square millimeter of fasciculus gracilis, at the C3 and T5 segments of spinal cord from 22 persons of different ages have been estimated, with a 95% confidence limit, assisted by semi-automatic methods of measurement and using programmed calculation and plotting. In addition, the histograms for diameter of myelinated fibers and mean diameter were obtained. At C3, the numbers of myelinated fibers ranged from 19,647/mm2 to 35,773/mm2, with a mean of 25,267/mm2. The number is less with older age. At T5, numbers of myelinated fibers ranged from 17,804/mm2 to 29,486/mm2, with a mean of 23,069/mm2. The number of myelinated fibers was greater at C3 than at T5 in subjects under 45. The mean diameter of myelinated fibers at C3 was smaller than that at T5. The normative data presented here should be useful for comparing with similarily derived data from patients with diseases of peripheral nerves, in evaluating the three-dimensional morphologic alteration of primary afferent neurons.
AB - The number of myelinated fibers per square millimeter of fasciculus gracilis, and of large and small myelinated fibers per square millimeter of fasciculus gracilis, at the C3 and T5 segments of spinal cord from 22 persons of different ages have been estimated, with a 95% confidence limit, assisted by semi-automatic methods of measurement and using programmed calculation and plotting. In addition, the histograms for diameter of myelinated fibers and mean diameter were obtained. At C3, the numbers of myelinated fibers ranged from 19,647/mm2 to 35,773/mm2, with a mean of 25,267/mm2. The number is less with older age. At T5, numbers of myelinated fibers ranged from 17,804/mm2 to 29,486/mm2, with a mean of 23,069/mm2. The number of myelinated fibers was greater at C3 than at T5 in subjects under 45. The mean diameter of myelinated fibers at C3 was smaller than that at T5. The normative data presented here should be useful for comparing with similarily derived data from patients with diseases of peripheral nerves, in evaluating the three-dimensional morphologic alteration of primary afferent neurons.
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U2 - 10.1016/0022-510X(76)90058-7
DO - 10.1016/0022-510X(76)90058-7
M3 - Article
C2 - 1249584
AN - SCOPUS:0017286630
SN - 0022-510X
VL - 27
SP - 163
EP - 172
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
IS - 2
ER -