More thoughts on plaques and tangles

Shu Hui Yen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Alzheimer neurofibrillary tangles (NFT) contain unique antigenic determinants and determinants in common with several normal cytoskeletal proteins which include the high molecular weight neurofilament proteins, microtubule associated proteins and vimentin. The unique determinants are found in nearly all NFT whereas the determinants in common with normal cytoskeletal proteins are generally detected only in a fraction of NFT. It remains to be determined whether a particular type of cytoskeletal protein is more involved than others in the formation of NFT and if posttranslational modification of certain normal proteins is responsible for the expression of unique antigenic determinants.

Original languageEnglish (US)
Pages (from-to)432-434
Number of pages3
JournalNeurobiology of Aging
Issue number6
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • General Psychology


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