Abstract
Alzheimer neurofibrillary tangles (NFT) contain unique antigenic determinants and determinants in common with several normal cytoskeletal proteins which include the high molecular weight neurofilament proteins, microtubule associated proteins and vimentin. The unique determinants are found in nearly all NFT whereas the determinants in common with normal cytoskeletal proteins are generally detected only in a fraction of NFT. It remains to be determined whether a particular type of cytoskeletal protein is more involved than others in the formation of NFT and if posttranslational modification of certain normal proteins is responsible for the expression of unique antigenic determinants.
Original language | English (US) |
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Pages (from-to) | 432-434 |
Number of pages | 3 |
Journal | Neurobiology of aging |
Volume | 7 |
Issue number | 6 |
DOIs | |
State | Published - 1986 |
ASJC Scopus subject areas
- Clinical Neurology
- Geriatrics and Gerontology
- Aging
- General Neuroscience
- Developmental Biology