Moral and scientific considerations in embryonic stem cell research

Zubin Master, Daisy Laforce, Marcus McLeod, Bryn Williams-Jones

Research output: Chapter in Book/Report/Conference proceedingChapter


The science of human embryonic stem (hES) cells holds tremendous promise for the discovery of revolutionary cellular therapeutic options for the restoration and regeneration of damaged or destroyed cells and tissues. Yet the fact that the derivation of hES cells from embryos normally results in the destruction of the embryo poses ethical challenges, which for some, amounts to a veritable impasse to the further development of stem cell science. In this article, we review the scientific and ethics literature on hES cells including the use of somatic cell nuclear transfer to generate cloned hES cells for biomedical research and potential clinical applications. The article reviews the various normative theories on the moral status of the human embryo that capture issues ranging from the continuity of embryonic development to cognitive prerequisites for personhood such as sentience, rationality and self-awareness. We also discuss arguments for the symbolic value of human embryos and the need to respect human embryos as potential persons. Beyond issues related to the destruction of human embryos, a number of other ethical issues germane to embryonic stem cell science are also considered, such as the instrumentalization and commercialization of human materials for stem cell research, and the potential social and health risks to women in obtaining and donating oocytes or embryos for hES cell research. Finally, ethical questions arising from the relatively recent development of scientific methods to create new types of embryos for harvesting hES cells are also discussed.

Original languageEnglish (US)
Title of host publicationPerspectives in Stem Cell Research
PublisherNova Science Publishers, Inc.
Number of pages51
ISBN (Print)9781611229851
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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