TY - JOUR
T1 - Monosomy 21 in hematologic diseases
AU - Van Dyke, Daniel L.
AU - Wiktor, Anne
PY - 2003/4/15
Y1 - 2003/4/15
N2 - Monosomy 21 mosaicism as a sole cytogenetic abnormality is very uncommon, with 47 cases described in the literature. We identified five cases of low-level monosomy 21 mosaicism since 1998, none of which were confirmed by fluorescence in situ hybridization (FISH) analysis or follow-up cytogenetic studies. These five cases, and many of the previously reported cases, probably represent the random appearance of several monosomy 21 cells as artifacts of cell culture or microscope slide preparation. The most convincing reported cases of monosomy 21 mosaicism suggest a rare association of monosomy 21 with acute myelocytic leukemia and chronic lymphocytic leukemia. Future cases suggestive of monosomy 21 mosaicism should be confirmed by analysis of additional metaphase cells and by FISH analysis of interphase cells.
AB - Monosomy 21 mosaicism as a sole cytogenetic abnormality is very uncommon, with 47 cases described in the literature. We identified five cases of low-level monosomy 21 mosaicism since 1998, none of which were confirmed by fluorescence in situ hybridization (FISH) analysis or follow-up cytogenetic studies. These five cases, and many of the previously reported cases, probably represent the random appearance of several monosomy 21 cells as artifacts of cell culture or microscope slide preparation. The most convincing reported cases of monosomy 21 mosaicism suggest a rare association of monosomy 21 with acute myelocytic leukemia and chronic lymphocytic leukemia. Future cases suggestive of monosomy 21 mosaicism should be confirmed by analysis of additional metaphase cells and by FISH analysis of interphase cells.
UR - http://www.scopus.com/inward/record.url?scp=0037446742&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037446742&partnerID=8YFLogxK
U2 - 10.1016/S0165-4608(02)00796-3
DO - 10.1016/S0165-4608(02)00796-3
M3 - Article
C2 - 12699891
AN - SCOPUS:0037446742
SN - 0165-4608
VL - 142
SP - 137
EP - 141
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -