TY - JOUR
T1 - Monosomal karyotype predicts adverse prognosis in patients diagnosed with chronic myelomonocytic leukemia
T2 - A single-institution experience
AU - Alsahlawi, Aysha
AU - Alkhateeb, Hassan
AU - Patnaik, Mrinal
AU - Begna, Kebede
AU - Elliott, Michelle
AU - Hogan, William J.
AU - Litzow, Mark
AU - Al-Kali, Aref
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Introduction Cytogenetic abnormalities have a significant prognostic effect in many hematologic neoplasms. Monosomal karyotype (MK), a newly recognized cytogenetic category, has been reported to be a marker of poor prognosis in patients with myelodysplastic syndromes and myelofibrosis, but its effect in chronic myelomonocytic leukemia (CMML) remains relatively unknown. Patients and Methods A retrospective study of cases diagnosed with CMML found a total of 262 patients. Patient characteristics, cytogenetic data, and survival were analyzed. Results Cytogenetic analysis found diploidy in 167 patients (64%). Trisomy 8 was the most frequent cytogenetic abnormality at 8% (22), followed by complex karyotype (CK) at 5% (14), -7 at 4% (10), and MK at 3% (7, of which 6 [86%] were also CK). Median overall survival was statistically significantly worse in MK-positive cases than in MK-negative cases (MK+ vs. MK-). Patients with MK+ only or CK+MK+ did worse than any other group. Conclusion MK is a rare entity but can predict statistically significantly shorter overall survival among all other cytogenetic categories.
AB - Introduction Cytogenetic abnormalities have a significant prognostic effect in many hematologic neoplasms. Monosomal karyotype (MK), a newly recognized cytogenetic category, has been reported to be a marker of poor prognosis in patients with myelodysplastic syndromes and myelofibrosis, but its effect in chronic myelomonocytic leukemia (CMML) remains relatively unknown. Patients and Methods A retrospective study of cases diagnosed with CMML found a total of 262 patients. Patient characteristics, cytogenetic data, and survival were analyzed. Results Cytogenetic analysis found diploidy in 167 patients (64%). Trisomy 8 was the most frequent cytogenetic abnormality at 8% (22), followed by complex karyotype (CK) at 5% (14), -7 at 4% (10), and MK at 3% (7, of which 6 [86%] were also CK). Median overall survival was statistically significantly worse in MK-positive cases than in MK-negative cases (MK+ vs. MK-). Patients with MK+ only or CK+MK+ did worse than any other group. Conclusion MK is a rare entity but can predict statistically significantly shorter overall survival among all other cytogenetic categories.
KW - CMML
KW - Cytogenetic analysis
KW - MK
KW - Prognosis
KW - Survival
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U2 - 10.1016/j.clml.2014.06.007
DO - 10.1016/j.clml.2014.06.007
M3 - Article
C2 - 25027568
AN - SCOPUS:84921738528
SN - 2152-2650
VL - 15
SP - e39-e41
JO - Clinical Lymphoma, Myeloma and Leukemia
JF - Clinical Lymphoma, Myeloma and Leukemia
IS - 2
ER -