Monoclonal gammopathy of undetermined significance: A consensus statement: Guideline

James R. Berenson, Kenneth C. Anderson, Robert A. Audell, Ralph V. Boccia, Morton Coleman, Meletios A. Dimopoulos, Matthew T. Drake, Rafael Fonseca, Jean Luc Harousseau, Douglas Joshua, Sagar Lonial, Ruben Niesvizky, Antonio Palumbo, G. David Roodman, Jesus F. San-Miguel, Seema Singhal, Donna M. Weber, Maurizio Zangari, Eric Wirtschafter, Ori YellinRobert A. Kyle

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations


On February 25, 2009, a panel of international experts on plasma cell dyscrasia and skeletal disease met to discuss monoclonal gammopathy of undetermined significance (MGUS). This non-malignant B-cell disorder is the most common plasma cell dyscrasia and is associated with an increased risk of developing serious B-cell disorders. Individuals with MGUS also have an increased risk of osteoporosis and osteopenia associated with an increased likelihood of developing fractures especially in the vertebral column, peripheral neuropathy and thromboembolic events. The goal of the meeting was to develop a consensus statement regarding the appropriate tests to screen, evaluate and follow-up patients with MGUS. The panel also addressed the identification and treatment of MGUS-related skeletal problems, thromboembolic events and neurological complications. The following consensus statement outlines the conclusions and marks the first time that a consensus statement for the screening and treatment of MGUS has been clearly stated.

Original languageEnglish (US)
Pages (from-to)28-38
Number of pages11
JournalBritish journal of haematology
Issue number1
StatePublished - Jul 2010


  • Fractures
  • Monoclonal gammopathy of undetermined significance
  • Osteoporosis
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Hematology


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