Monoclonal Gammopathy of Undetermined Significance

Research output: Contribution to journalArticlepeer-review


Monoclonal gammopathy of undetermined significance (MGUS) is of considerable clinical importance to primary care physicians given its high prevalence in the general population. MGUS has a variable but lifelong risk for progression to hematologic cancer, such as multiple myeloma, Waldenström macroglobulinemia, or light-chain amyloidosis. In addition, MGUS has been associated with several nonmalignant yet symptomatic disorders that require therapy directed toward eliminating the monoclonal gammopathy. Thus, it is important not only to understand the essentials of diagnosing and monitoring patients with MGUS but also to recognize when to refer patients with MGUS to a specialist.

Original languageEnglish (US)
Pages (from-to)177-190
Number of pages14
JournalAnnals of internal medicine
Issue number12
StatePublished - Dec 1 2022

ASJC Scopus subject areas

  • Internal Medicine


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