TY - JOUR
T1 - Monoclonal Gammopathy of Undetermined Significance
AU - Gonsalves, Wilson I.
AU - Rajkumar, S. Vincent
N1 - Publisher Copyright:
© 2022 American College of Physicians.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Monoclonal gammopathy of undetermined significance (MGUS) is of considerable clinical importance to primary care physicians given its high prevalence in the general population. MGUS has a variable but lifelong risk for progression to hematologic cancer, such as multiple myeloma, Waldenström macroglobulinemia, or light-chain amyloidosis. In addition, MGUS has been associated with several nonmalignant yet symptomatic disorders that require therapy directed toward eliminating the monoclonal gammopathy. Thus, it is important not only to understand the essentials of diagnosing and monitoring patients with MGUS but also to recognize when to refer patients with MGUS to a specialist.
AB - Monoclonal gammopathy of undetermined significance (MGUS) is of considerable clinical importance to primary care physicians given its high prevalence in the general population. MGUS has a variable but lifelong risk for progression to hematologic cancer, such as multiple myeloma, Waldenström macroglobulinemia, or light-chain amyloidosis. In addition, MGUS has been associated with several nonmalignant yet symptomatic disorders that require therapy directed toward eliminating the monoclonal gammopathy. Thus, it is important not only to understand the essentials of diagnosing and monitoring patients with MGUS but also to recognize when to refer patients with MGUS to a specialist.
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U2 - 10.7326/AITC202212200
DO - 10.7326/AITC202212200
M3 - Article
C2 - 36508741
AN - SCOPUS:85144589711
SN - 0003-4819
VL - 175
SP - 177
EP - 190
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 12
ER -