Monoclonal gammopathy of undetermined significance

Robert A. Kyle, S. Vincent Rajkumar

Research output: Chapter in Book/Report/Conference proceedingChapter


The term monoclonal gammopathy of undetermined significance (MGUS) denotes the presence of a monoclonal protein (M protein) in persons without evidence of multiple myeloma (MM), Waldenström's macroglobulinemia (WM), AL amyloidosis (AL), or other related diseases. MGUS is characterized by a serum M-protein concentration of less than 3.0 g/dL; less than 10 % clonal plasma cells in the bone marrow; and the absence of end-organ damage (CRAB-hypercalcemia, renal insufficiency, anemia, and bone lesions) related to the plasma cell proliferative disorder [1-4].

Original languageEnglish (US)
Title of host publicationNeoplastic Diseases of the Blood
PublisherSpringer New York
Number of pages35
ISBN (Electronic)9781461437642
ISBN (Print)1461437636, 9781461437635
StatePublished - Nov 1 2013


  • Long-term outcome of MGUS
  • MGUS association with other diseases
  • MGUS prevalence
  • Risk factors for progression of MGUS
  • Variants of MGUS

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Monoclonal gammopathy of undetermined significance'. Together they form a unique fingerprint.

Cite this