Abstract
A 31-year-old patient in remission of acute lymphoblastic leukaemia (ALL), receiving oral maintenance chemotherapy (6-mercaptopurine, methotrexate (MTX), cyclophosphamide), developed a monoclonal, Epstein-Barr virus (EBV)-related lymphoproliferative disorder (LPD). Treatment consisted of excisional biopsy and the discontinuation of maintenance chemotherapy. To our knowledge, this is the first such report in an adult. The histological similarity to previous reports of 'lymphomatoid granulomatosis' following paediatric ALL suggests that they are the same disease. MTX may play a central role in the development of LPD in this setting. Although it is a rare complication of ALL, EBV-related LPD should be considered in patients who develop lymphadenopathy.
Original language | English (US) |
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Pages (from-to) | 713-716 |
Number of pages | 4 |
Journal | British journal of haematology |
Volume | 106 |
Issue number | 3 |
DOIs | |
State | Published - 1999 |
Keywords
- ALL
- EBV
- Lymphomatoid granulomatosis
- Lymphoproliferative disorder
- Methotrexate
ASJC Scopus subject areas
- Hematology