Monitoring activity of fibrinolytic agents. A therapeutic challenge

Kenneth E. Shafer, Samuel A. Santoro, Burton E. Sobel, Allan S. Jaffe

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


The recognition that thrombolytic therapy may be beneficial for coronary thrombolysis has led to an increased use of plasminogen activators in critically ill patients, sometimes with inadequate monitoring. This review delineates the components of the fibrinolytic system, describes mechanisms of fibrinolysis, and presents practical guidelines for monitoring the use of activators of the system.

Original languageEnglish (US)
Pages (from-to)879-886
Number of pages8
JournalThe American Journal of Medicine
Issue number5
StatePublished - May 1984

ASJC Scopus subject areas

  • General Medicine


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