Molecular mechanisms of Cryptosporidium-induced host actin cytoskeleton dynamics

Steven P. O'hara, Xian Ming Chen, Nicholas F. LaRusso

Research output: Chapter in Book/Report/Conference proceedingChapter


Early ultrastructural observations of Cryptosporidium parvum-infected cells consistentlydescribed the accumulation of microfilaments beneath the dense band, suggesting theinitiation of actin reorganization within the host cell. Immunolocalization and forcedexpression of β-actin green fluorescent protein confirmed the rearrangement of hostactin filaments, and recruitment of actin-binding proteins to infection sites. Subsequentstudies have demonstrated the importance of host signalling cascades leading to actinreorganization during early invasion events. Therefore, this chapter focuses on actin reorganizationduring sporozoite internalization and development, concentrating primarilyon the molecular mechanisms of actin reorganization.

Original languageEnglish (US)
Title of host publicationGiardia and Cryptosporidium
Subtitle of host publicationFrom Molecules to Diseases
PublisherCABI Publishing
Number of pages10
ISBN (Print)9781845933913
StatePublished - Feb 25 2009

ASJC Scopus subject areas

  • General Veterinary
  • General Agricultural and Biological Sciences


Dive into the research topics of 'Molecular mechanisms of Cryptosporidium-induced host actin cytoskeleton dynamics'. Together they form a unique fingerprint.

Cite this