Molecular genetics of soft-tissue sarcomas: A brief overview for clinical oncologists

Jorge Torres-Mora; Karen J. Fritchie; Steven I. Robinson; Andre M. Oliveira

doi:10.1097/PPO.0000000000000026

Molecular genetics of soft-tissue sarcomas: A brief overview for clinical oncologists

Jorge Torres-Mora, Karen J. Fritchie, Steven I. Robinson, Andre M. Oliveira

Medical Oncology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors with distinct lines of differentiation and biologic behavior. Currently, histological analysis is still the main diagnostic approach for the classification of STSs. However, ancillary molecular genetic methods are becoming increasingly important for diagnostic confirmation and therapeutic considerations. Herein, we provide a brief overview of clinically relevant molecular abnormalities of STSs for the general clinical oncologist.

Original language	English (US)
Pages (from-to)	73-79
Number of pages	7
Journal	Cancer Journal (United States)
Volume	20
Issue number	1
DOIs	https://doi.org/10.1097/PPO.0000000000000026
State	Published - 2014

Keywords

Soft-tissue sarcomas (STSs)
ancillary molecular genetic methods
classification
histological analysis

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1097/PPO.0000000000000026

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title = "Molecular genetics of soft-tissue sarcomas: A brief overview for clinical oncologists",

abstract = "Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors with distinct lines of differentiation and biologic behavior. Currently, histological analysis is still the main diagnostic approach for the classification of STSs. However, ancillary molecular genetic methods are becoming increasingly important for diagnostic confirmation and therapeutic considerations. Herein, we provide a brief overview of clinically relevant molecular abnormalities of STSs for the general clinical oncologist.",

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AU - Fritchie, Karen J.

AU - Robinson, Steven I.

AU - Oliveira, Andre M.

PY - 2014

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AB - Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors with distinct lines of differentiation and biologic behavior. Currently, histological analysis is still the main diagnostic approach for the classification of STSs. However, ancillary molecular genetic methods are becoming increasingly important for diagnostic confirmation and therapeutic considerations. Herein, we provide a brief overview of clinically relevant molecular abnormalities of STSs for the general clinical oncologist.

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KW - ancillary molecular genetic methods

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KW - histological analysis

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Molecular genetics of soft-tissue sarcomas: A brief overview for clinical oncologists

Abstract

Keywords

ASJC Scopus subject areas

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