Molecular genetic changes in solid pseudopapillary neoplasms (SPN) of the pancreas

Elisa Rodriguez-Matta, Amanda Hemmerich, Jason Starr, Kabir Mody, Eric A. Severson, Gerardo Colon-Otero

Research output: Contribution to journalLetterpeer-review

Original languageEnglish (US)
Pages (from-to)1024-1027
Number of pages4
JournalActa Oncologica
StatePublished - 2020


  • Solid pseudopapillary neoplasms of the pancreas are commonly associated with pathogenic point mutations in the CTNNB1 gene. Our series identified CTNNB1 mutations in 93% of the cases
  • each in 29% of the cases
  • most commonly in positions 32 and 37. Additional pathogenic mutations in other cancer associated genes are common
  • present in 64% of our cases. Comprehensive genomic profiling identified potentially actionable genomic alterations and mutations in DNA repair genes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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