TY - JOUR
T1 - Molecular Biomarker Testing for the Diagnosis of Diffuse Gliomas:Guideline from the College of American Pathologists in Collaboration with the American Association of Neuropathologists, Association for Molecular Pathology, and Society for Neuro-Oncology
AU - Brat, Daniel J.
AU - Aldape, Kenneth
AU - Bridge, Julia A.
AU - Canoll, Peter
AU - Colman, Howard
AU - Hameed, Meera R.
AU - Harris, Brent T.
AU - Hattab, Eyas M.
AU - Huse, Jason T.
AU - Jenkins, Robert B.
AU - Lopez-Terrada, Dolores H.
AU - McDonald, William C.
AU - Rodriguez, Fausto J.
AU - Souter, Lesley H.
AU - Colasacco, Carol
AU - Thomas, Nicole E.
AU - Hawks Yount, Michelle
AU - van den Bent, Martin J.
AU - Perry, Arie
N1 - Publisher Copyright:
© 2022 College of American Pathologists. All rights reserved.
PY - 2022/5
Y1 - 2022/5
N2 - • Context.—The diagnosis and clinical management of patients with diffuse gliomas (DGs) have evolved rapidly over the past decade with the emergence of molecular biomarkers that are used to classify, stratify risk, and predict treatment response for optimal clinical care. Objective.—To develop evidence-based recommendations for informing molecular biomarker testing for pediatric and adult patients with DGs and provide guidance for appropriate laboratory test and biomarker selection for optimal diagnosis, risk stratification, and prediction. Design.—The College of American Pathologists convened an expert panel to perform a systematic review of the literature and develop recommendations. A systematic review of literature was conducted to address the overarching question, ‘‘What ancillary tests are needed to classify DGs and sufficiently inform the clinical management of patients?’’ Recommendations were derived from quality of evidence, open comment feedback, and expert panel consensus. Results.—Thirteen recommendations and 3 good practice statements were established to guide pathologists and treating physicians on the most appropriate methods and molecular biomarkers to include in laboratory testing to inform clinical management of patients with DGs. Conclusions.—Evidence-based incorporation of laboratory results from molecular biomarker testing into integrated diagnoses of DGs provides reproducible and clinically meaningful information for patient management.
AB - • Context.—The diagnosis and clinical management of patients with diffuse gliomas (DGs) have evolved rapidly over the past decade with the emergence of molecular biomarkers that are used to classify, stratify risk, and predict treatment response for optimal clinical care. Objective.—To develop evidence-based recommendations for informing molecular biomarker testing for pediatric and adult patients with DGs and provide guidance for appropriate laboratory test and biomarker selection for optimal diagnosis, risk stratification, and prediction. Design.—The College of American Pathologists convened an expert panel to perform a systematic review of the literature and develop recommendations. A systematic review of literature was conducted to address the overarching question, ‘‘What ancillary tests are needed to classify DGs and sufficiently inform the clinical management of patients?’’ Recommendations were derived from quality of evidence, open comment feedback, and expert panel consensus. Results.—Thirteen recommendations and 3 good practice statements were established to guide pathologists and treating physicians on the most appropriate methods and molecular biomarkers to include in laboratory testing to inform clinical management of patients with DGs. Conclusions.—Evidence-based incorporation of laboratory results from molecular biomarker testing into integrated diagnoses of DGs provides reproducible and clinically meaningful information for patient management.
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U2 - 10.5858/arpa.2021-0295-CP
DO - 10.5858/arpa.2021-0295-CP
M3 - Article
C2 - 35175291
AN - SCOPUS:85129345178
SN - 0003-9985
VL - 146
SP - 547
EP - 574
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 5
ER -