Molecular and cellular mechanisms of estrogen action on the skeleton

D. J. Rickard, M. Subramaniam, T. C. Spelsberg

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


The many recent and exciting advances that have taken place in the field of estrogen action on the skeleton are the subjects of this review. Leading these new developments is the discovery of alternative estrogen receptors that exhibit differential mechanisms of transcriptional control of estrogen- responsive promoters, thereby broadening both the ranges of possible target cells and their responses. More potentially important genes under estrogenic control have been identified in vitro, and the skeletal phenotypes caused by disruption of estrogen signaling due to mutations in humans and mice have been described. Lastly, clinical studies in humans have revealed a greater appreciation for the importance of estrogen in bone mass maintenance in both sexes.

Original languageEnglish (US)
Pages (from-to)123-132
Number of pages10
JournalJournal of cellular biochemistry
Issue numberSUPPL. 32/33
StatePublished - 1999


  • Bone cells
  • Estrogen action
  • Estrogen analogues

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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