Molecular abnormalities in colorectal cancer: Microsatellite instability pathway

J. M. Cunningham; L. A. Boardman; L. J. Burgart; S. N. Thibodeau

Molecular abnormalities in colorectal cancer: Microsatellite instability pathway

J. M. Cunningham, L. A. Boardman, L. J. Burgart, S. N. Thibodeau

Research output: Contribution to journal › Article › peer-review

Abstract

The expansion and contraction of microsatellite DNA in colon cancer (microsatellite instability) has provided the first strong experimental support for a mutator phenotype in cancer. As a result of this and other key observations, several human DNA mismatch repair genes, in particular hMLH1 and hMSH2, have now been implicated in this process. Tumors harboring such a mutator phenotype appear to have distinctive genetic, pathologic, and clinical characteristics.

Original language	English (US)
Pages (from-to)	38-48
Number of pages	11
Journal	Seminars in Colon and Rectal Surgery
Volume	9
Issue number	1
State	Published - Jan 1 1998

ASJC Scopus subject areas

Surgery
Gastroenterology

Cite this

@article{4ff078f35b31449a845bdce8d6a15d74,

title = "Molecular abnormalities in colorectal cancer: Microsatellite instability pathway",

abstract = "The expansion and contraction of microsatellite DNA in colon cancer (microsatellite instability) has provided the first strong experimental support for a mutator phenotype in cancer. As a result of this and other key observations, several human DNA mismatch repair genes, in particular hMLH1 and hMSH2, have now been implicated in this process. Tumors harboring such a mutator phenotype appear to have distinctive genetic, pathologic, and clinical characteristics.",

author = "Cunningham, {J. M.} and Boardman, {L. A.} and Burgart, {L. J.} and Thibodeau, {S. N.}",

year = "1998",

month = jan,

day = "1",

language = "English (US)",

volume = "9",

pages = "38--48",

journal = "Seminars in Colon and Rectal Surgery",

issn = "1043-1489",

publisher = "W.B. Saunders Ltd",

number = "1",

}

TY - JOUR

T1 - Molecular abnormalities in colorectal cancer

T2 - Microsatellite instability pathway

AU - Cunningham, J. M.

AU - Boardman, L. A.

AU - Burgart, L. J.

AU - Thibodeau, S. N.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - The expansion and contraction of microsatellite DNA in colon cancer (microsatellite instability) has provided the first strong experimental support for a mutator phenotype in cancer. As a result of this and other key observations, several human DNA mismatch repair genes, in particular hMLH1 and hMSH2, have now been implicated in this process. Tumors harboring such a mutator phenotype appear to have distinctive genetic, pathologic, and clinical characteristics.

AB - The expansion and contraction of microsatellite DNA in colon cancer (microsatellite instability) has provided the first strong experimental support for a mutator phenotype in cancer. As a result of this and other key observations, several human DNA mismatch repair genes, in particular hMLH1 and hMSH2, have now been implicated in this process. Tumors harboring such a mutator phenotype appear to have distinctive genetic, pathologic, and clinical characteristics.

UR - http://www.scopus.com/inward/record.url?scp=0031945274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031945274&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031945274

SN - 1043-1489

VL - 9

SP - 38

EP - 48

JO - Seminars in Colon and Rectal Surgery

JF - Seminars in Colon and Rectal Surgery

IS - 1

ER -

Molecular abnormalities in colorectal cancer: Microsatellite instability pathway

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this