Modulating actions of estradiol on gonadotropin-releasing hormone—stimulated prolactin secretion in postmenopausal individuals

Elisabeth Christiansen, Johannes D. Veldhuis, Alan D. Rogol, Paul Stumpf, William S. Evans

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


The temporal aspects of estrogen treatment on serum prolactin concentrations basally and in response to a 10 μg intravenous injection of gonadotropin-releasing hormone were assessed in eight postmenopausal women. The response of prolactin to gonadotropin-releasing hormone stimulation was compared with that of follicle-stimulating hormone and luteinizing hormone obtained simultaneously. Basal serum prolactin increased significantly (p < 0.001) in response to estrogen treatment, and a positive correlation was found between the serum concentrations of estradiol and prolactin (r2 = 0.266; p = 0.0011). Gonadotropin-releasing hormone induced a significant increase in serum prolactin concentrations, which was greater after 5 to 10 days of estrogen treatment compared with that in the estrogen-depleted state (p = 0.031). No correlation was found between gonadotropin-releasing hormone-stimulated prolactin and luteinizing hormone or follicle-stimulating hormone release. These data demonstrate that estrogen treatment of previously hypoestrogenemic postmenopausal women potentiates gonadotropin-releasing hormone-stimulated prolactin release. Furthermore, our data suggest that the previously described paracrine interaction between the gonadotropens and lactotropes exerted by gonadotropin-releasing hormone does not appear to be mediated via increased gonadotropin release.

Original languageEnglish (US)
Pages (from-to)320-325
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Issue number2
StatePublished - 1987


  • Prolactin
  • estradiol
  • gonadotropin-releasing hormone

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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