TY - JOUR
T1 - Modulating actions of estradiol on gonadotropin-releasing hormone—stimulated prolactin secretion in postmenopausal individuals
AU - Christiansen, Elisabeth
AU - Veldhuis, Johannes D.
AU - Rogol, Alan D.
AU - Stumpf, Paul
AU - Evans, William S.
PY - 1987
Y1 - 1987
N2 - The temporal aspects of estrogen treatment on serum prolactin concentrations basally and in response to a 10 μg intravenous injection of gonadotropin-releasing hormone were assessed in eight postmenopausal women. The response of prolactin to gonadotropin-releasing hormone stimulation was compared with that of follicle-stimulating hormone and luteinizing hormone obtained simultaneously. Basal serum prolactin increased significantly (p < 0.001) in response to estrogen treatment, and a positive correlation was found between the serum concentrations of estradiol and prolactin (r2 = 0.266; p = 0.0011). Gonadotropin-releasing hormone induced a significant increase in serum prolactin concentrations, which was greater after 5 to 10 days of estrogen treatment compared with that in the estrogen-depleted state (p = 0.031). No correlation was found between gonadotropin-releasing hormone-stimulated prolactin and luteinizing hormone or follicle-stimulating hormone release. These data demonstrate that estrogen treatment of previously hypoestrogenemic postmenopausal women potentiates gonadotropin-releasing hormone-stimulated prolactin release. Furthermore, our data suggest that the previously described paracrine interaction between the gonadotropens and lactotropes exerted by gonadotropin-releasing hormone does not appear to be mediated via increased gonadotropin release.
AB - The temporal aspects of estrogen treatment on serum prolactin concentrations basally and in response to a 10 μg intravenous injection of gonadotropin-releasing hormone were assessed in eight postmenopausal women. The response of prolactin to gonadotropin-releasing hormone stimulation was compared with that of follicle-stimulating hormone and luteinizing hormone obtained simultaneously. Basal serum prolactin increased significantly (p < 0.001) in response to estrogen treatment, and a positive correlation was found between the serum concentrations of estradiol and prolactin (r2 = 0.266; p = 0.0011). Gonadotropin-releasing hormone induced a significant increase in serum prolactin concentrations, which was greater after 5 to 10 days of estrogen treatment compared with that in the estrogen-depleted state (p = 0.031). No correlation was found between gonadotropin-releasing hormone-stimulated prolactin and luteinizing hormone or follicle-stimulating hormone release. These data demonstrate that estrogen treatment of previously hypoestrogenemic postmenopausal women potentiates gonadotropin-releasing hormone-stimulated prolactin release. Furthermore, our data suggest that the previously described paracrine interaction between the gonadotropens and lactotropes exerted by gonadotropin-releasing hormone does not appear to be mediated via increased gonadotropin release.
KW - Prolactin
KW - estradiol
KW - gonadotropin-releasing hormone
UR - http://www.scopus.com/inward/record.url?scp=0023395294&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023395294&partnerID=8YFLogxK
U2 - 10.1016/S0002-9378(87)80161-8
DO - 10.1016/S0002-9378(87)80161-8
M3 - Article
C2 - 3113249
AN - SCOPUS:0023395294
SN - 0002-9378
VL - 157
SP - 320
EP - 325
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 2
ER -