Models of coxsackievirus-B3-induced myocarditis: Recent advances

De Lisa Fairweather; Noel R. Rose

doi:10.1016/j.ddmod.2004.11.003

Models of coxsackievirus-B3-induced myocarditis: Recent advances

De Lisa Fairweather, Noel R. Rose

Cardiovascular Diseases

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Currently, animal models are available that closely resemble human myocarditis. Coxsackievirus B3 (CVB3)-induced myocarditis models fall into two major categories: direct viral damage models and virus-triggered autoimmune models. Debate focuses on whether CVB3 can cause autoimmune heart disease or whether myocardial inflammation is due to direct damage or persistence of virus. Recent findings strengthen the argument that CVB3 triggers autoimmune myocarditis in mice without the requirement for active viral replication.

Original language	English (US)
Pages (from-to)	381-386
Number of pages	6
Journal	Drug Discovery Today: Disease Models
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/j.ddmod.2004.11.003
State	Published - Dec 2004

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmod.2004.11.003

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title = "Models of coxsackievirus-B3-induced myocarditis: Recent advances",

abstract = "Currently, animal models are available that closely resemble human myocarditis. Coxsackievirus B3 (CVB3)-induced myocarditis models fall into two major categories: direct viral damage models and virus-triggered autoimmune models. Debate focuses on whether CVB3 can cause autoimmune heart disease or whether myocardial inflammation is due to direct damage or persistence of virus. Recent findings strengthen the argument that CVB3 triggers autoimmune myocarditis in mice without the requirement for active viral replication.",

author = "Fairweather, {De Lisa} and Rose, {Noel R.}",

note = "Funding Information: Research presented in this article was supported by National Institutes of Health grants HL67290, HL70729 and AI51835.",

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AU - Rose, Noel R.

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N2 - Currently, animal models are available that closely resemble human myocarditis. Coxsackievirus B3 (CVB3)-induced myocarditis models fall into two major categories: direct viral damage models and virus-triggered autoimmune models. Debate focuses on whether CVB3 can cause autoimmune heart disease or whether myocardial inflammation is due to direct damage or persistence of virus. Recent findings strengthen the argument that CVB3 triggers autoimmune myocarditis in mice without the requirement for active viral replication.

AB - Currently, animal models are available that closely resemble human myocarditis. Coxsackievirus B3 (CVB3)-induced myocarditis models fall into two major categories: direct viral damage models and virus-triggered autoimmune models. Debate focuses on whether CVB3 can cause autoimmune heart disease or whether myocardial inflammation is due to direct damage or persistence of virus. Recent findings strengthen the argument that CVB3 triggers autoimmune myocarditis in mice without the requirement for active viral replication.

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Models of coxsackievirus-B3-induced myocarditis: Recent advances

Abstract

ASJC Scopus subject areas

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