Modeling shear modulus distribution in magnetic resonance elastography with piecewise constant level sets

Bing Nan Li, Chee Kong Chui, Sim Heng Ong, Tomokazu Numano, Toshikatsu Washio, Kazuhiro Homma, Stephen Chang, Sudhakar Venkatesh, Etsuko Kobayashi

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Magnetic resonance elastography (MRE) is designed for imaging the mechanical properties of soft tissues. However, the interpretation of shear modulus distribution is often confusing and cumbersome. For reliable evaluation, a common practice is to specify the regions of interest and consider regional elasticity. Such an experience-dependent protocol is susceptible to intrapersonal and interpersonal variability. In this study we propose to remodel shear modulus distribution with piecewise constant level sets by referring to the corresponding magnitude image. Optimal segmentation and registration are achieved by a new hybrid level set model comprised of alternating global and local region competitions. Experimental results on the simulated MRE data sets show that the mean error of elasticity reconstruction is 11.33% for local frequency estimation and 18.87% for algebraic inversion of differential equation. Piecewise constant level set modeling is effective to improve the quality of shear modulus distribution, and facilitates MRE analysis and interpretation.

Original languageEnglish (US)
Pages (from-to)390-401
Number of pages12
JournalMagnetic Resonance Imaging
Issue number3
StatePublished - Apr 2012


  • Elasticity imaging
  • Level set methods
  • Magnetic resonance elastography
  • Registration
  • Segmentation

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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