MK-801 attenuates capillary bed compression and hypoperfusion following incomplete focal cerebral ischemia

Fredric B. Meyer; Robert E. Anderson; Patricia F. Friedrich

doi:10.1038/jcbfm.1990.146

MK-801 attenuates capillary bed compression and hypoperfusion following incomplete focal cerebral ischemia

Fredric B. Meyer, Robert E. Anderson, Patricia F. Friedrich

Neurosurgery

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The effects of the N-methyl-D-aspartate (NMDA) antagonist MK-801 on capillary beds and CBF following 1 h of transient incomplete focal cerebral ischemia were studied by examining ¹³³Xe CBF, capillary diameter, and area of perfused vasculature. Capillary diameter increased from a control of 5.24 ± 0.37 to 8.62 ± 0.57 μm (p < 0.001) and area of perfused vasculature from 20,943 ± 1,151 to 30,442 ± 1,691 μm²/×10 magnification field (p < 0.001) with MK-801 1.0 mg/kg administered 30 min prior to ischemia. After flow restoration in control animals, there was a relative hypoperfusion with eventual normalization of CBF over 60 min. Alterna-tively, in MK-801 1.0 mg/kg animals, there was rapid normalization of CBF upon flow restoration without the postischemic hypoperfusion observed in controls. On histological analysis, there was consistently less neuronal edema in MK-801-treated animals. These results support the hypothesis that hypoperfusion folowing incomplete focal cerebral ischemia may be due in part to NMDA-mediated cellular edema with subsequent extravascular capillary bed compression.

Original language	English (US)
Pages (from-to)	895-902
Number of pages	8
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	10
Issue number	6
DOIs	https://doi.org/10.1038/jcbfm.1990.146
State	Published - 1990

Keywords

Capillary
Cerebral blood flow
Excitatory amino acids
N-methyl-d-aspartate receptor
Postischemic hypoperfusion

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cardiology and Cardiovascular Medicine

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10.1038/jcbfm.1990.146

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title = "MK-801 attenuates capillary bed compression and hypoperfusion following incomplete focal cerebral ischemia",

abstract = "The effects of the N-methyl-D-aspartate (NMDA) antagonist MK-801 on capillary beds and CBF following 1 h of transient incomplete focal cerebral ischemia were studied by examining 133Xe CBF, capillary diameter, and area of perfused vasculature. Capillary diameter increased from a control of 5.24 ± 0.37 to 8.62 ± 0.57 μm (p < 0.001) and area of perfused vasculature from 20,943 ± 1,151 to 30,442 ± 1,691 μm2/×10 magnification field (p < 0.001) with MK-801 1.0 mg/kg administered 30 min prior to ischemia. After flow restoration in control animals, there was a relative hypoperfusion with eventual normalization of CBF over 60 min. Alterna-tively, in MK-801 1.0 mg/kg animals, there was rapid normalization of CBF upon flow restoration without the postischemic hypoperfusion observed in controls. On histological analysis, there was consistently less neuronal edema in MK-801-treated animals. These results support the hypothesis that hypoperfusion folowing incomplete focal cerebral ischemia may be due in part to NMDA-mediated cellular edema with subsequent extravascular capillary bed compression.",

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author = "Meyer, {Fredric B.} and Anderson, {Robert E.} and Friedrich, {Patricia F.}",

year = "1990",

doi = "10.1038/jcbfm.1990.146",

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AU - Anderson, Robert E.

AU - Friedrich, Patricia F.

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AB - The effects of the N-methyl-D-aspartate (NMDA) antagonist MK-801 on capillary beds and CBF following 1 h of transient incomplete focal cerebral ischemia were studied by examining 133Xe CBF, capillary diameter, and area of perfused vasculature. Capillary diameter increased from a control of 5.24 ± 0.37 to 8.62 ± 0.57 μm (p < 0.001) and area of perfused vasculature from 20,943 ± 1,151 to 30,442 ± 1,691 μm2/×10 magnification field (p < 0.001) with MK-801 1.0 mg/kg administered 30 min prior to ischemia. After flow restoration in control animals, there was a relative hypoperfusion with eventual normalization of CBF over 60 min. Alterna-tively, in MK-801 1.0 mg/kg animals, there was rapid normalization of CBF upon flow restoration without the postischemic hypoperfusion observed in controls. On histological analysis, there was consistently less neuronal edema in MK-801-treated animals. These results support the hypothesis that hypoperfusion folowing incomplete focal cerebral ischemia may be due in part to NMDA-mediated cellular edema with subsequent extravascular capillary bed compression.

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KW - Postischemic hypoperfusion

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MK-801 attenuates capillary bed compression and hypoperfusion following incomplete focal cerebral ischemia

Abstract

Keywords

ASJC Scopus subject areas

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