TY - JOUR
T1 - Mismatch repair deficiency as prognostic factor for stage III small bowel adenocarcinoma
T2 - A multicentric international study
AU - Vanoli, Alessandro
AU - Guerini, Camilla
AU - Arpa, Giovanni
AU - Klersy, Catherine
AU - Grillo, Federica
AU - Casadei Gardini, Andrea
AU - De Hertogh, Gert
AU - Ferrante, Marc
AU - Moens, Annick
AU - Furlan, Daniela
AU - Sessa, Fausto
AU - Quaquarini, Erica
AU - Lenti, Marco Vincenzo
AU - Neri, Giuseppe
AU - Macciomei, Maria Cristina
AU - Fassan, Matteo
AU - Cascinu, Stefano
AU - Paulli, Marco
AU - Graham, Rondell Patrell
AU - Di Sabatino, Antonio
N1 - Publisher Copyright:
© 2023 Editrice Gastroenterologica Italiana S.r.l.
PY - 2023/9
Y1 - 2023/9
N2 - Background: Small bowel adenocarcinoma (SBA) is a rare cancer with an aggressive behavior. No study has specifically addressed the putative prognostic role of mismatch repair status in stage III SBAs. Aims: We aimed to investigate whether mismatch repair deficiency is associated with cancer-specific survival in a Western cohort of patients with stage III SBAs. Methods: In this retrospective multicentric international cohort study, we enrolled 70 patients who underwent surgically resection for stage III SBAs and we analyzed the frequency of mismatch repair deficiency, tested by immunohistochemistry for mismatch repair proteins and by polymerase chain reaction for microsatellite instability, and its association with cancer-specific survival and other clinic-pathologic factors. Results: We found sixteen (23%) patients with mismatch repair deficient adenocarcinoma, without discordance between immunohistochemical and polymerase chain reaction for microsatellite instability analyses. Mismatch repair deficiency proved to be associated with a better outcome both at univariable analysis (hazard ratio: 0.28, 95% confidence interval: 0.08–0.91, p: 0.035) and in bivariable models adjusted for patient age or gender, tumor site, pT4 stage, tumor budding, and perineural invasion. Conclusion: This study highlights the importance of testing mismatch repair status to improve prognostic stratification in stage III SBAs.
AB - Background: Small bowel adenocarcinoma (SBA) is a rare cancer with an aggressive behavior. No study has specifically addressed the putative prognostic role of mismatch repair status in stage III SBAs. Aims: We aimed to investigate whether mismatch repair deficiency is associated with cancer-specific survival in a Western cohort of patients with stage III SBAs. Methods: In this retrospective multicentric international cohort study, we enrolled 70 patients who underwent surgically resection for stage III SBAs and we analyzed the frequency of mismatch repair deficiency, tested by immunohistochemistry for mismatch repair proteins and by polymerase chain reaction for microsatellite instability, and its association with cancer-specific survival and other clinic-pathologic factors. Results: We found sixteen (23%) patients with mismatch repair deficient adenocarcinoma, without discordance between immunohistochemical and polymerase chain reaction for microsatellite instability analyses. Mismatch repair deficiency proved to be associated with a better outcome both at univariable analysis (hazard ratio: 0.28, 95% confidence interval: 0.08–0.91, p: 0.035) and in bivariable models adjusted for patient age or gender, tumor site, pT4 stage, tumor budding, and perineural invasion. Conclusion: This study highlights the importance of testing mismatch repair status to improve prognostic stratification in stage III SBAs.
KW - Celiac disease
KW - Crohn's disease
KW - Immune-mediated disorders
KW - Immunotherapy
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U2 - 10.1016/j.dld.2023.05.005
DO - 10.1016/j.dld.2023.05.005
M3 - Article
C2 - 37236851
AN - SCOPUS:85160258757
SN - 1590-8658
VL - 55
SP - 1261
EP - 1269
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
IS - 9
ER -