Mild cognitive impairment as a risk factor for Parkinson's disease dementia

on behalf of the MDS Study Group “Validation of Mild Cognitive Impairment in Parkinson Disease”

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Background: The International Parkinson and Movement Disorder Society criteria for mild cognitive impairment in PD were recently formulated. Objectives: The aim of this international study was to evaluate the predictive validity of the comprehensive (level II) version of these criteria by assessment of their contribution to the hazard of PD dementia. Methods: Individual patient data were selected from four separate studies on cognition in PD that provided information on demographics, motor examination, depression, neuropsychological examination suitable for application of level II criteria, and longitudinal follow-up for conversion to dementia. Survival analysis evaluated the predictive value of level II criteria for cognitive decline toward dementia as expressed by the relative hazard of dementia. Results: A total of 467 patients were included. The analyses showed a clear contribution of impairment according to level II mild cognitive impairment criteria, age, and severity of PD motor symptoms to the hazard of dementia. There was a trend of increasing hazard of dementia with declining neuropsychological performance. Conclusions: This is the first large international study evaluating the predictive validity of level II mild cognitive impairment criteria for PD. The results showed a clear and unique contribution of classification according to level II criteria to the hazard of PD dementia. This finding supports their predictive validity and shows that they contribute important new information on the hazard of dementia, beyond known demographic and PD-specific factors of influence.

Original languageEnglish (US)
Pages (from-to)1056-1065
Number of pages10
JournalMovement Disorders
Issue number7
StatePublished - Jul 2017


  • Parkinson's disease
  • dementia
  • mild cognitive impairment
  • neuropsychological tests
  • survival analyses

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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