MicroRNAs in the cholangiopathies: Pathogenesis, diagnosis, and treatment

Maria Jose Lorenzo Pisarello, Lorena Loarca, Tommy Ivanics, Leslie Morton, Nicholas LaRusso

Research output: Contribution to journalReview articlepeer-review


The cholangiopathies are a group of liver diseases resulting from different etiologies but with the cholangiocyte as the primary target. As a group, the cholangiopathies result in significant morbidity and mortality and represent one of the main indications for liver transplant in both children and adults. Contributing to this situation is the absence of a thorough understanding of their pathogenesis and a lack of adequate diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that modify gene expression post-transcriptionally. They have been implicated in the pathogenesis of many diseases, including the cholangiopathies. Thus, in this review we provide an overview of the literature on miRNAs in the cholangiopathies and discuss future research directions.

Original languageEnglish (US)
Pages (from-to)1688-1712
Number of pages25
JournalJournal of Clinical Medicine
Issue number9
StatePublished - Aug 26 2015


  • Cholangiocarcinoma
  • Cholangiopathies
  • MicroRNA

ASJC Scopus subject areas

  • General Medicine


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