Microporous polysaccharide hemospheres for management of laparoscopic trocar injury to the spleen

Mitchell R. Humphreys, Erik P. Castle, Paul E. Andrews, Matthew T. Gettman, Mark H. Ereth

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Background: Management of iatrogenic injuries during laparoscopy can be arduous. Recent advancements in surgical hemostatic agents have provided beneficial therapeutic alternatives. This project evaluates microporous polysaccharide hemospheres (MPH), with demonstrated efficiency achieving topical hemostasis, in the setting of intracorporeal laparoscopic splenic injury. Methods: Four domestic female pigs were subjected to reproducible laparoscopic 12-mm and 5-mm trocar splenic injuries. Each surgery was an identical transperitoneal hand-assisted laparoscopic procedure. Hemostasis, or no bleeding after treatment, was achieved by measured dose applications of MPH. Results: The MPH successfully achieved hemostasis for all splenic injuries except in 1 case, where a 12-mm lesion transected the splenic artery. The mean time to hemostasis, applications of MPH, and estimated blood loss for the 5- and 12-mm injuries were 165.3 ± 45.7 and 200.7 ± 106.5 seconds, 1.3 ± .5 applications for both, and 12.0 ± 4.6 and 17.7 ± 9.1g, respectively. Conclusions: MPH represents a powerful hemostatic agent that demonstrated complete hemostasis for iatrogenic splenic injury.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalAmerican journal of surgery
Issue number1
StatePublished - Jan 1 2008


  • Hemostatic agents
  • Laparoscopic hemostasis
  • Splenic injury

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Microporous polysaccharide hemospheres for management of laparoscopic trocar injury to the spleen'. Together they form a unique fingerprint.

Cite this