Microglial P2Y12 receptor regulates seizure-induced neurogenesis and immature neuronal projections

Mingshu Mo, Ukpong B. Eyo, Manling Xie, Jiyun Peng, Dale B. Bosco, Anthony D. Umpierre, Xiaoqin Zhu, Dai Shi Tian, Pingyi Xu, Long Jun Wu

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Seizures are common in humans with various etiologies ranging from congenital aberrations to acute injuries that alter the normal balance of brain excitation and inhibition. A notable consequence of seizures is the induction of aberrant neurogenesis and increased immature neuronal projections. However, regulatory mechanisms governing these features during epilepsy development are not fully understood. Recent studies show that microglia, the brain's resident immune cell, contribute to normal neurogenesis and regulate seizure phenotypes. However, the role of microglia in aberrant neurogenic seizure contexts has not been adequately investigated. To address this question, we coupled the intracerebroventricular kainic acid model with current pharmacogenetic approaches to eliminate microglia in male mice. We show that microglia promote seizure-induced neurogenesis and subsequent seizure-induced immature neuronal projections above and below the pyramidal neurons between the DG and the CA3 regions. Furthermore, we identify microglial P2Y12 receptors (P2Y12R) as a participant in this neurogenic process.

Original languageEnglish (US)
Pages (from-to)9453-9464
Number of pages12
JournalJournal of Neuroscience
Issue number47
StatePublished - Nov 20 2019


  • Immature Projections
  • Microglia
  • Neurogenesis
  • P2Y12R
  • Seizures

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Microglial P2Y12 receptor regulates seizure-induced neurogenesis and immature neuronal projections'. Together they form a unique fingerprint.

Cite this