Microenvironment-Mediated Resistance to Anti-Androgen Therapy

Jacob J. Orme, Haojie Huang

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations


In this issue of Cancer Cell, Zhang et al. expose new possibilities for targeting castration-resistant prostate cancer (CRPC). Activation of the HER2/HER3 axis by cancer-associated fibroblast-secreted NRG1 mediates castration resistance, recommending novel applications of clinical anti-NRG1/HER3 therapeutics in treating CRPC.

Original languageEnglish (US)
Pages (from-to)155-157
Number of pages3
JournalCancer cell
Issue number2
StatePublished - Aug 10 2020

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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