Microbiology of Bone and Joint Infections

Seong Yeol Ryu, Robin Patel

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


This chapter discusses microorganisms in osteomyelitis, microorganisms in implant-associated bone and joint infection, microorganisms in native joint arthritis, diagnostic approach in osteomyelitis, and diagnostic approach in native joint infection. Osteomyelitis can occur as a result of contiguous spread from surrounding soft tissues or joints. Alternatively, it may result from hematogenous seeding or direct inoculation of microorganisms into the bone. In hematogenous osteomyelitis, infection is typically monobacterial, whereas in contiguous (exogenous) infection, it is often polymicrobial. Although the diagnostic value of serum C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR) is limited due to their low specificity, they may be useful to follow the response to therapy. Septic arthritis is considered an emergency because of the potential for rapid joint destruction with irreversible loss of function.

Original languageEnglish (US)
Title of host publicationBone and Joint Infections: From Microbiology to Diagnostics and Treatment
PublisherWiley Blackwell
Number of pages16
ISBN (Electronic)9781118581742
ISBN (Print)9781118581773
StatePublished - Jan 30 2015


  • C-reactive protein (CRP) levels
  • Chronic osteomyelitis
  • Erythrocyte sedimentation rate (ESR)
  • Joint infections
  • Microorganisms
  • Native joint arthritis
  • Septic arthritis

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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